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<p>We report the first in situ reaction of the β-haloketones obtained from laccase catalysed oxidation of secondary alcohol 2-halo phenylethanol’s in present study. To the best of our knowledge, this is the first ever fusion of laccase catalysed oxidation reaction with green organic synthetic reaction. The methodology employs molecular oxygen to oxidize secondary alcohol in biphasic medium by laccase from <i>T. giganteum</i> AGHP, to obtain β-haloketones. This research provides environmentally benign access to thiazole, β-ketosulfone and imidazopyridine derivatives in good to very good yields with wide functional group tolerance.</p> Graphical Abstract <p>Green method for synthesis of thiazoles, imidazopyridines and <i>β</i>-keto sulfones were synthesised by using fusion of laccase catalysed enzymatic oxidation with the green organic annulation reaction</p> <p></p>

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Laccase Mediated One-Pot, Green Synthesis of Thiazoles, β-Keto Sulfones and Imidazopyridines

  • 期刊论文

  • 发表日期：

    2025年1月9日

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  • Sanjay S. Gaikwad,
  • Mehul M. Hiwale,
  • Shankesh C. Zyate,
  • Santosh B. Gaikwad,
  • Suresh B. Waghmode,
  • Amardeep R. Jadhao

摘要

We report the first in situ reaction of the β-haloketones obtained from laccase catalysed oxidation of secondary alcohol 2-halo phenylethanol’s in present study. To the best of our knowledge, this is the first ever fusion of laccase catalysed oxidation reaction with green organic synthetic reaction. The methodology employs molecular oxygen to oxidize secondary alcohol in biphasic medium by laccase from T. giganteum AGHP, to obtain β-haloketones. This research provides environmentally benign access to thiazole, β-ketosulfone and imidazopyridine derivatives in good to very good yields with wide functional group tolerance.

Graphical Abstract

Green method for synthesis of thiazoles, imidazopyridines and β-keto sulfones were synthesised by using fusion of laccase catalysed enzymatic oxidation with the green organic annulation reaction