<p>Infectious diseases are primarily caused by pathogens from the environment that invade the human body. Obstructing this infection route is thus crucial for prevention. Our current research focused on the development of a novel material for multiple-contact infection prophylaxis. We recently developed a promising supramolecular material, called poly-γ-glutamate ion-complex (PGAIC), which is synthesized using poly-γ-glutamate and cetylpyridinium. However, its preventiveness against human pathogens, such as the novel coronavirus, <i>Serratia</i> bacteria, and dermatophytes, remained unclear. In this research, we prove the triple (<i>i.e.</i>, anti-SARSCoV-2, anti-<i>Serratia</i>, and anti-<i>Trichophyton</i>) protective performance of PGAIC and propose a feasible application of PGAIC coatings in public health management.</p> Graphical abstract <p></p>

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Rapid formulation and application of poly-γ-glutamate into an ultrabroad-spectrum, safer microbicidal coating

  • Toma Onari,
  • Makoto Ashiuchi

摘要

Infectious diseases are primarily caused by pathogens from the environment that invade the human body. Obstructing this infection route is thus crucial for prevention. Our current research focused on the development of a novel material for multiple-contact infection prophylaxis. We recently developed a promising supramolecular material, called poly-γ-glutamate ion-complex (PGAIC), which is synthesized using poly-γ-glutamate and cetylpyridinium. However, its preventiveness against human pathogens, such as the novel coronavirus, Serratia bacteria, and dermatophytes, remained unclear. In this research, we prove the triple (i.e., anti-SARSCoV-2, anti-Serratia, and anti-Trichophyton) protective performance of PGAIC and propose a feasible application of PGAIC coatings in public health management.

Graphical abstract