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<p>In this study, a novel double-layer coating was successfully fabricated on the AZ31 magnesium alloy through the combination of dip-coating and electrospinning techniques. The coating is composed of an inner gelatin (Gel) layer and an outer layer made of electrospun fibers consisting of silk fibroin (RSF) and hydroxypropyltrimethyl ammonium chloride chitosan (HACC). The scanning electron microscope analysis indicated that the RSF-HACC overlayer possesses a dense structure, as evidenced by its smaller fiber diameter and reduced pore size in comparison to the pure RSF fibrous layer. The RSF/HACC fiber coating showed a higher water contact angle (78.7 ± 2.5°) in comparison with the RSF fiber coating (30.1 ± 2.4°). The Gel layer, along with the incorporation of HACC, enhanced the adhesion strength of the RSF-HACC fiber coating, effectively preventing the fiber coating from detaching from the substrate. Electrochemical tests demonstrated that Mg alloy coated with the Gel/RSF-HACC double-layer structure exhibited a lower annual corrosion rate and superior corrosion resistance compared to the other samples. In vitro cell experiments and the antibacterial tests have demonstrated excellent cytocompatibility and a good inhibitory effect for the sample coated with Gel/RSF-HACC. The aim of this research is not only to enhance the corrosion resistance, cytocompatibility, and antibacterial properties of&#xa0;Mg&#xa0;alloy&#xa0;through the double-layer coating, but also to provide an innovative approach to increase the adhesion between substrate and the electrospun fibrous coating utilizing a Gel layer.</p> Graphical abstract <p></p>

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A silk fibroin/HACC electrospun fibrous coating on Mg alloy for enhanced adhesion strength, corrosion resistance, and biocompatibility via a gelatin layer

  • 期刊论文

  • 发表日期：

    2025年11月10日

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  • Chao Zhang,
  • Qi Ding,
  • Qiqi Lu,
  • Xinru Wang,
  • Jing Sun,
  • Jingjing Liu,
  • Yong Liu,
  • Ying Li,
  • Wei Ye

摘要

In this study, a novel double-layer coating was successfully fabricated on the AZ31 magnesium alloy through the combination of dip-coating and electrospinning techniques. The coating is composed of an inner gelatin (Gel) layer and an outer layer made of electrospun fibers consisting of silk fibroin (RSF) and hydroxypropyltrimethyl ammonium chloride chitosan (HACC). The scanning electron microscope analysis indicated that the RSF-HACC overlayer possesses a dense structure, as evidenced by its smaller fiber diameter and reduced pore size in comparison to the pure RSF fibrous layer. The RSF/HACC fiber coating showed a higher water contact angle (78.7 ± 2.5°) in comparison with the RSF fiber coating (30.1 ± 2.4°). The Gel layer, along with the incorporation of HACC, enhanced the adhesion strength of the RSF-HACC fiber coating, effectively preventing the fiber coating from detaching from the substrate. Electrochemical tests demonstrated that Mg alloy coated with the Gel/RSF-HACC double-layer structure exhibited a lower annual corrosion rate and superior corrosion resistance compared to the other samples. In vitro cell experiments and the antibacterial tests have demonstrated excellent cytocompatibility and a good inhibitory effect for the sample coated with Gel/RSF-HACC. The aim of this research is not only to enhance the corrosion resistance, cytocompatibility, and antibacterial properties of Mg alloy through the double-layer coating, but also to provide an innovative approach to increase the adhesion between substrate and the electrospun fibrous coating utilizing a Gel layer.

Graphical abstract