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<p>Bioseparation encompasses a range of unit operations, including extraction, concentration, purification, and polishing, used to isolate proteins, polyphenols, and other biomolecules from complex food matrices. This paper discusses the fundamentals and industrial methods of food bioseparation science and technology. Ultrasound, enzymes, microwaves, and supercritical fluid extraction are examined alongside sustainable deep eutectic solvents and aqueous two-phase systems. The review covers recent advances in chromatographic, membrane-based, hybrid, and continuous separation techniques. This review examines ion-exchange and simulated moving bed (SMB) chromatography alongside membrane filtration techniques, including ultrafiltration (UF), nanofiltration (NF), and reverse osmosis (RO), for the purification of proteins and nucleic acids in food systems. Case studies in food biotechnology, such as whey protein recovery, plant protein isolation, and nucleotide production, employ continuous biomanufacturing and integrated upstream and downstream systems. Mechanistic process modeling, artificial intelligence (AI), and machine learning tools for process optimization, monitoring, and control are also examined. Emphasis is placed on water and solvent recycling, food-byproduct valorization, energy-efficient operations, and circular bioeconomy models. Emerging technologies include hybrid separation platforms, digital twin integration, and eco-designed separation materials. These advancements make bioseparation vital for the sustainability, scalability, and quality of food processing in the coming decade.</p>

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Recent Developments in Bioseparation for Food Processing: Principles, Technologies, and Sustainable Applications

  • 期刊论文

  • 发表日期：

    2026年4月24日

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  • Tejaswi Boyapati,
  • Gayathri M. S. Priyadharshini,
  • Kasiviswanathan Muthukumarappan,
  • Payel Ghosh

摘要

Bioseparation encompasses a range of unit operations, including extraction, concentration, purification, and polishing, used to isolate proteins, polyphenols, and other biomolecules from complex food matrices. This paper discusses the fundamentals and industrial methods of food bioseparation science and technology. Ultrasound, enzymes, microwaves, and supercritical fluid extraction are examined alongside sustainable deep eutectic solvents and aqueous two-phase systems. The review covers recent advances in chromatographic, membrane-based, hybrid, and continuous separation techniques. This review examines ion-exchange and simulated moving bed (SMB) chromatography alongside membrane filtration techniques, including ultrafiltration (UF), nanofiltration (NF), and reverse osmosis (RO), for the purification of proteins and nucleic acids in food systems. Case studies in food biotechnology, such as whey protein recovery, plant protein isolation, and nucleotide production, employ continuous biomanufacturing and integrated upstream and downstream systems. Mechanistic process modeling, artificial intelligence (AI), and machine learning tools for process optimization, monitoring, and control are also examined. Emphasis is placed on water and solvent recycling, food-byproduct valorization, energy-efficient operations, and circular bioeconomy models. Emerging technologies include hybrid separation platforms, digital twin integration, and eco-designed separation materials. These advancements make bioseparation vital for the sustainability, scalability, and quality of food processing in the coming decade.