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<p>Fucoxanthin (FX), a hydrophobic carotenoid, exhibits enhanced solubility and bioactivity when combined with lipids. However, its co-encapsulation with conjugated linoleic acid (CLA) remains challenging due to their mutual sensitivity to light, heat, and oxygen. Herein, we developed complex liposomes co-loading FX and CLA via ethanol injection, followed by sequential coating with chitosan and sodium alginate through electrostatic deposition. The resulting polymer-coated liposomes (S-C–CL) achieved a high FX encapsulation efficiency of 80.15 ± 1.23%. Post-modification, the particle size increased to 3684.33 ± 203.05&#xa0;nm with a zeta potential of − 45.73 ± 2.77&#xa0;mV, indicating a dense polyelectrolyte shell. Structural analyses (TEM, FT-IR) confirmed successful encapsulation and coating. The modified liposomes exhibited significantly improved thermal stability (phase transition temperature increased from 47.6&#xa0;°C to 145.6&#xa0;°C) and storage stability. This work provides a robust strategy for stabilizing FX-loaded liposomal systems for functional food applications.</p>

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Preparation and Stability of Fucoxanthin and Conjugated Linoleic Acid Complex Liposomes

  • 期刊论文

  • 发表日期：

    2026年1月13日

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  • Shuangshuang Wu,
  • Hongchun Dong,
  • Xuhui Lei,
  • Yuan Meng,
  • Jinwen Zhao,
  • Yimeng Ren,
  • Yichao Ma,
  • Yunhai He,
  • Dandan Ren

摘要

Fucoxanthin (FX), a hydrophobic carotenoid, exhibits enhanced solubility and bioactivity when combined with lipids. However, its co-encapsulation with conjugated linoleic acid (CLA) remains challenging due to their mutual sensitivity to light, heat, and oxygen. Herein, we developed complex liposomes co-loading FX and CLA via ethanol injection, followed by sequential coating with chitosan and sodium alginate through electrostatic deposition. The resulting polymer-coated liposomes (S-C–CL) achieved a high FX encapsulation efficiency of 80.15 ± 1.23%. Post-modification, the particle size increased to 3684.33 ± 203.05 nm with a zeta potential of − 45.73 ± 2.77 mV, indicating a dense polyelectrolyte shell. Structural analyses (TEM, FT-IR) confirmed successful encapsulation and coating. The modified liposomes exhibited significantly improved thermal stability (phase transition temperature increased from 47.6 °C to 145.6 °C) and storage stability. This work provides a robust strategy for stabilizing FX-loaded liposomal systems for functional food applications.