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<p><span>l</span>-Tryptophan (Trp) is an important amino acid in the human diet: It is responsible for the healthy function of the nervous and immune systems. The direct inclusion of Trp into food products is often difficult because of its strong bitter taste. We created an encapsulation platform to mask Trp’s unpalatable flavor. High loading content and minimum usage of toxic reagents are desirable in the food industry; therefore, we have fabricated microcapsules from ethyl cellulose (EC) and hydroxypropyl cellulose through solid-oil-oil (S–O-O) emulsion and solvent evaporation. The microcapsules produced had high encapsulation efficiency (66–81%) and good loading content (~ 16–39%). The resulting microcapsule also showed strong cargo retention at pH 3.2 and pH 7.0 over 8&#xa0;h (~ 20% release). Considering gastrointestinal transit time, the inclusion of hydroxypropyl cellulose was successfully used to modulate the cumulative release within this window without major alteration to loading. When up to 20 w/w% of the EC shell material was substituted by hydroxypropyl cellulose, the microcapsule showed a 10% cumulative release at 1&#xa0;h and 59% release at 8&#xa0;h. In addition, modification of EC with citric acid also accelerated cargo release.</p>

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Fabrication of Ethyl Cellulose and Hydroxypropyl Cellulose Composite Microcapsules via Solid-Oil-Oil Emulsion for Encapsulation of l-Tryptophan

  • 期刊论文

  • 发表日期：

    2025年5月30日

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  • Benjamin Pomon,
  • Annika Madler,
  • Xieergai Jiang,
  • Alireza Abbaspourrad

摘要

l-Tryptophan (Trp) is an important amino acid in the human diet: It is responsible for the healthy function of the nervous and immune systems. The direct inclusion of Trp into food products is often difficult because of its strong bitter taste. We created an encapsulation platform to mask Trp’s unpalatable flavor. High loading content and minimum usage of toxic reagents are desirable in the food industry; therefore, we have fabricated microcapsules from ethyl cellulose (EC) and hydroxypropyl cellulose through solid-oil-oil (S–O-O) emulsion and solvent evaporation. The microcapsules produced had high encapsulation efficiency (66–81%) and good loading content (~ 16–39%). The resulting microcapsule also showed strong cargo retention at pH 3.2 and pH 7.0 over 8 h (~ 20% release). Considering gastrointestinal transit time, the inclusion of hydroxypropyl cellulose was successfully used to modulate the cumulative release within this window without major alteration to loading. When up to 20 w/w% of the EC shell material was substituted by hydroxypropyl cellulose, the microcapsule showed a 10% cumulative release at 1 h and 59% release at 8 h. In addition, modification of EC with citric acid also accelerated cargo release.