Scholarlink

Purpose of Review <p>This review examines the potential of vaccine-based strategies in preventing and modifying the progression of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Amyotrophic Lateral Sclerosis, and Creutzfeldt-Jakob Disease. It explores the pathophysiology of these diseases and highlights the challenges in developing effective vaccines, such as crossing the blood–brain barrier and achieving precise immune modulation.</p> Recent Findings <p>Advances in vaccine technologies, including messenger RNA (mRNA) platforms, novel delivery systems, plant-based vaccines, and gene-editing approaches, have shown promise in enhancing immunogenicity and specificity. These innovations address key obstacles in targeting neurodegenerative pathologies and present opportunities for preventive and therapeutic interventions. Ethical considerations and public health implications further show the importance of interdisciplinary research efforts.</p> Summary <p>Vaccine-based strategies hold significant promise in addressing the unmet needs of neurodegenerative disease prevention and treatment. However, translating these advancements into clinical applications requires sustained research, robust clinical trials, and a focus on ethical and regulatory frameworks. Interdisciplinary collaboration is critical to accelerate progress and improve outcomes for patients at risk of or affected by neurodegenerative disorders.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Vaccine Based Approaches for the Prevention and Treatment of Neurological Disease

  • 期刊论文

  • 发表日期：

    2025年1月30日

查看全文
  • Nicholas Aderinto,
  • Israel Charles Abraham,
  • Gbolahan Olatunji,
  • Emmanuel Kokori,
  • Patrick Ashinze,
  • Emmanuel Adeoba Babawale,
  • Badrudeen Olalekan Alabi,
  • Olaewe David Opeyemi,
  • Adetola Emmanuel Babalola,
  • Ayoola Ikeoluwa Oluwapelumi,
  • Chidinma Udojike,
  • Okikiola Sobuur Fagbolade,
  • Festus Oluseye Babarinde,
  • Ololade Wiquoyat Oyesiji,
  • Bonaventure Michael Ukoaka,
  • Alexander Idu Entonu,
  • Matthew Tolulope Olawoyin,
  • Olayinka Fakorede

摘要

Purpose of Review

This review examines the potential of vaccine-based strategies in preventing and modifying the progression of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Amyotrophic Lateral Sclerosis, and Creutzfeldt-Jakob Disease. It explores the pathophysiology of these diseases and highlights the challenges in developing effective vaccines, such as crossing the blood–brain barrier and achieving precise immune modulation.

Recent Findings

Advances in vaccine technologies, including messenger RNA (mRNA) platforms, novel delivery systems, plant-based vaccines, and gene-editing approaches, have shown promise in enhancing immunogenicity and specificity. These innovations address key obstacles in targeting neurodegenerative pathologies and present opportunities for preventive and therapeutic interventions. Ethical considerations and public health implications further show the importance of interdisciplinary research efforts.

Summary

Vaccine-based strategies hold significant promise in addressing the unmet needs of neurodegenerative disease prevention and treatment. However, translating these advancements into clinical applications requires sustained research, robust clinical trials, and a focus on ethical and regulatory frameworks. Interdisciplinary collaboration is critical to accelerate progress and improve outcomes for patients at risk of or affected by neurodegenerative disorders.