Trends and Innovations in Heart Transplantation: Donor Procurement, Organ Preservation, and Evolving Therapies
摘要
Heart transplantation has witnessed significant advancements over the past decade in donor types (Donation after Brain Death DBD vs. Donation after Circulatory Death DCD), procurement techniques (Direct Procurement DPP vs. Normothermic Regional Perfusion NRP), organ preservation methods (Static Cold Storage SCS, SherpaPak Cardiac Transport System SCTS, ex vivo perfusion systems), and immunosuppressive therapies. A critical review of these emerging technologies is essential to enable their thoughtful and timely adoption by institutions and to enhance transplant outcomes.
Recent FindingsHeart transplantation using DCD donors demonstrates post-transplant survival and graft function outcomes comparable to those of DBD donors. However, nuances in donor procurement techniques and organ preservation strategies remain critical determinants in optimizing transplantation success.
SummaryThere are now multiple strategies available for heart donation, necessitating a stepwise, structured approach to decision-making. Balancing recipient and donor risk profiles, procurement logistics, societal costs, ethical considerations, risks of primary graft dysfunction (PGD), and short- and long-term survival outcomes is essential when selecting the optimal heart donor procurement strategy