Scholarlink

Purpose of Review <p>Older patients can be at higher risk of toxicity with chemotherapy due to frailty, which can have significant impacts on quality of life. Older adults have been historically underrepresented in clinical trials, making it difficult to generalize safety data for chemotherapy regimens in those with geriatric risk factors. This review aims to highlight the influence of frailty on chemotherapy tolerance and quality of life in older adults with cancer, and discusses the utilization of geriatric assessment to guide treatment decision-making and mitigate treatment related toxicity.</p> Recent Findings <p>Geriatric assessment (GA) reliably identifies frailty and other geriatric risk factors that predispose patients to chemotherapy toxicity, functional decline, and diminished quality of life. Utilizing GA regularly in practice can mitigate these risks by impacting treatment choices or proactively addressing vulnerabilities in an older patient. Care of older adults should involve a multidisciplinary team to identify deficits and successfully implement interventions.</p> Summary <p>Tailoring therapy based on deficits identified during geriatric assessment can reduce risks associated with chemotherapy and promote independence and quality of life in patients. Future research should focus on safe and effective therapeutic strategies in frail older adults.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Frailty and Quality of Life in Older Patients Treated with Chemotherapy

  • 期刊论文

  • 发表日期：

    2026年2月18日

查看全文
  • Christine Sam,
  • Inés Alvarez Granda,
  • Martine Extermann

摘要

Purpose of Review

Older patients can be at higher risk of toxicity with chemotherapy due to frailty, which can have significant impacts on quality of life. Older adults have been historically underrepresented in clinical trials, making it difficult to generalize safety data for chemotherapy regimens in those with geriatric risk factors. This review aims to highlight the influence of frailty on chemotherapy tolerance and quality of life in older adults with cancer, and discusses the utilization of geriatric assessment to guide treatment decision-making and mitigate treatment related toxicity.

Recent Findings

Geriatric assessment (GA) reliably identifies frailty and other geriatric risk factors that predispose patients to chemotherapy toxicity, functional decline, and diminished quality of life. Utilizing GA regularly in practice can mitigate these risks by impacting treatment choices or proactively addressing vulnerabilities in an older patient. Care of older adults should involve a multidisciplinary team to identify deficits and successfully implement interventions.

Summary

Tailoring therapy based on deficits identified during geriatric assessment can reduce risks associated with chemotherapy and promote independence and quality of life in patients. Future research should focus on safe and effective therapeutic strategies in frail older adults.