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Purpose of Review <p>To highlight the unique clinical features, risk factors, and management strategies associated with early-onset Parkinson’s disease (EOPD), and contrast these with late-onset Parkinson’s disease (LOPD). We outline how these differences influence diagnostic and therapeutic approaches and identify key knowledge gaps critical to improving clinical care.</p> Recent Findings <p> Compared to LOPD, EOPD (onset age 21-50) has a higher prevalence of monogenic risk factors, focal dystonia, depression, anxiety; slower motor progression; lower rates of cognitive decline; higher risk for delayed diagnosis. Treatment is complicated by earlier and more frequent dyskinesias, motor fluctuations, and unique considerations such as pregnancy and career impact.</p> Summary <p> Risk factors, clinical presentation, progression, and management needs of EOPD can differ from LOPD. Despite advances in characterizing and diagnosing EOPD, most research remains focused on LOPD. There is a critical need to tailor research and clinical trials to address the distinct needs of people with EOPD. </p>

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Early-Onset Parkinson’s Disease: Unique Features and Management Approaches

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月18日

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  • Jordan Hickman,
  • Andrew Tsai,
  • Michelle Fullard,
  • Michael Korsmo,
  • Emily Forbes,
  • Sana Aslam,
  • Alexander J. Baumgartner,
  • Jeanne S. Feuerstein,
  • Ece Bayram

摘要

Purpose of Review

To highlight the unique clinical features, risk factors, and management strategies associated with early-onset Parkinson’s disease (EOPD), and contrast these with late-onset Parkinson’s disease (LOPD). We outline how these differences influence diagnostic and therapeutic approaches and identify key knowledge gaps critical to improving clinical care.

Recent Findings

Compared to LOPD, EOPD (onset age 21-50) has a higher prevalence of monogenic risk factors, focal dystonia, depression, anxiety; slower motor progression; lower rates of cognitive decline; higher risk for delayed diagnosis. Treatment is complicated by earlier and more frequent dyskinesias, motor fluctuations, and unique considerations such as pregnancy and career impact.

Summary

Risk factors, clinical presentation, progression, and management needs of EOPD can differ from LOPD. Despite advances in characterizing and diagnosing EOPD, most research remains focused on LOPD. There is a critical need to tailor research and clinical trials to address the distinct needs of people with EOPD.