From Efficacy to Implementation: Integrating Palliative Care after the PAL-LIVER Trial
摘要
This narrative examines how palliative care can be effectively integrated into routine management of advanced liver disease (ALD). It evaluates the gap between evidence supporting palliative care and its limited adoption in hepatology practice, focusing on implementation needs.
Recent findingsThe multisite cluster randomized PAL-LIVER trial demonstrated that integrated palliative care improves quality of life, symptom burden, and patient satisfaction in ALD. However, uptake in routine practice remains inconsistent because of challenges involving patient identification, workforce capacity, workflow integration, reimbursement, and inequities in access.
SummaryEvidence supports the benefits of palliative care integration in ALD, but translation into clinical practice remains limited. Key priorities for future research include developing scalable care models, improving workforce training, redesigning workflows, establishing quality metrics, integration into transplant and addressing reimbursement barriers. An implementation-focused research agenda is needed to support sustainable and equitable integration of palliative care into hepatology practice.