Purpose of Review <p>This review addresses recent advances in the pre- and post-transplant clinical course and treatment of patients with autoimmune hepatitis (AIH), as well as current insights on disease recurrence.</p> Recent Findings <p>Patients transplanted for AIH have generally good outcomes after transplant but are at higher risk of rejection, disease recurrence, and infection than non-autoimmune liver diseases. There is no standardized post-transplant immunosuppression approach for this population.</p> Summary <p>Immunosuppression following liver transplantation for AIH should balance graft survival with disease recurrence and rejection while minimizing adverse outcomes of long-term immunosuppression. Future research should aim to address knowledge gaps related to the prevention, early detection, and treatment of AIH recurrence in high-risk populations. Appropriate characterization of these patients is essential to optimize and tailor their post-transplant care.</p>

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Liver Transplantation for Autoimmune Hepatitis and Risk of Recurrent Disease

  • Natalia Salinas Parra,
  • Therese Bittermann

摘要

Purpose of Review

This review addresses recent advances in the pre- and post-transplant clinical course and treatment of patients with autoimmune hepatitis (AIH), as well as current insights on disease recurrence.

Recent Findings

Patients transplanted for AIH have generally good outcomes after transplant but are at higher risk of rejection, disease recurrence, and infection than non-autoimmune liver diseases. There is no standardized post-transplant immunosuppression approach for this population.

Summary

Immunosuppression following liver transplantation for AIH should balance graft survival with disease recurrence and rejection while minimizing adverse outcomes of long-term immunosuppression. Future research should aim to address knowledge gaps related to the prevention, early detection, and treatment of AIH recurrence in high-risk populations. Appropriate characterization of these patients is essential to optimize and tailor their post-transplant care.