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Purpose of Review <p>To compile research evaluating low- versus high-dose aspirin efficacy and safety in patients with known cardiovascular disease.</p> Recent Findings <p>The ADAPTABLE randomized controlled trial of ~ 1,500 participants with cardiovascular disease found similar ischemic efficacy and bleeding safety of low- versus high-dose aspirin at a median follow-up of 26 months.</p> Summary <p>High-dose aspirin does not have improved efficacy and increases bleeding risk in secondary cardiovascular disease prevention. As such, patients with cardiovascular disease should be maintained on low-dose aspirin.</p>

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Aspirin Dosing in Secondary Prevention of Atherosclerotic Cardiovascular Disease

  • 期刊论文

  • 发表日期：

    2026年3月25日

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  • Kadijah Porter,
  • Isaac Acquah,
  • Adrienne Walker,
  • Shea E. Hogan

摘要

Purpose of Review

To compile research evaluating low- versus high-dose aspirin efficacy and safety in patients with known cardiovascular disease.

Recent Findings

The ADAPTABLE randomized controlled trial of ~ 1,500 participants with cardiovascular disease found similar ischemic efficacy and bleeding safety of low- versus high-dose aspirin at a median follow-up of 26 months.

Summary

High-dose aspirin does not have improved efficacy and increases bleeding risk in secondary cardiovascular disease prevention. As such, patients with cardiovascular disease should be maintained on low-dose aspirin.