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Purpose of Review <p>To provide clinicians with a concise introduction of microplastics potential role as a cardiovascular risk factor.</p> Recent Findings <p>Microplastics have been identified in human cardiovascular tissues. In vitro and animal-based studies associate microplastics presence with increased oxidative stress, endothelial dysfunction, platelet aggregation disruption, and low-grade inflammation. Small human studies report associations between intraplaque or circulating microplastics and cardiovascular outcomes. However, these signals are associative, method-dependent, and vulnerable to exposure misclassification, co-pollutant confounding, contamination, and heterogeneous analytics.</p> Summary <p>Microplastics are pervasive and biologically plausible as a cardiovascular risk factor, supported by growing in-vitro evidence and incipient human association studies. Cohesive population-level measures to curb MP pollution should be embedded within policies addressing broader environmental cardiovascular risk factors. For clinicians, it remains premature to recommend personal-level mitigation strategies, and MPs are best regarded as an emerging exposure within the patient’s exposome that warrants awareness and further rigorous studies.</p>

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Microplastics and Cardiovascular Disease: Should Clinicians Be Paying Attention?

  • 期刊论文

  • 发表日期：

    2025年11月27日

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  • Pedro Rafael Vieira de Oliveira Salerno,
  • Ricardo J. Estrada-Mendizabal,
  • Coral Lozada,
  • Sarju Ganatra,
  • Mohamed Bassiony,
  • Omar Aboukhatwa,
  • Colin Carpenter,
  • Sadeer Al-Kindi

摘要

Purpose of Review

To provide clinicians with a concise introduction of microplastics potential role as a cardiovascular risk factor.

Recent Findings

Microplastics have been identified in human cardiovascular tissues. In vitro and animal-based studies associate microplastics presence with increased oxidative stress, endothelial dysfunction, platelet aggregation disruption, and low-grade inflammation. Small human studies report associations between intraplaque or circulating microplastics and cardiovascular outcomes. However, these signals are associative, method-dependent, and vulnerable to exposure misclassification, co-pollutant confounding, contamination, and heterogeneous analytics.

Summary

Microplastics are pervasive and biologically plausible as a cardiovascular risk factor, supported by growing in-vitro evidence and incipient human association studies. Cohesive population-level measures to curb MP pollution should be embedded within policies addressing broader environmental cardiovascular risk factors. For clinicians, it remains premature to recommend personal-level mitigation strategies, and MPs are best regarded as an emerging exposure within the patient’s exposome that warrants awareness and further rigorous studies.