<p>Since being isolated by Viale and Weiß in 2009, the Guessing Model Property has emerged as a particularly prominent and powerful consequence of the Proper Forcing Axiom. In this paper, we investigate connections between variations of the Guessing Model Property and cardinal arithmetic, broadly construed. We improve upon results of Viale and Krueger by proving that a weakening of the Guessing Model Property implies Shelah’s Strong Hypothesis. We also prove that, though the Guessing Model Property is known not to put an upper bound on the size of the continuum, it does imply that 2^<i>ω</i>1 is as small as possible relative to the value of 2^<i>ω</i>. Building on work of Laver, we prove that, in the extension of any model of PFA by a measure algebra, every tree of height and size <i>ω</i>₁ is B-special (a generalization of specialness introduced by Baumgartner that can also hold of trees with uncountable branches). Finally, we investigate the impact of forcing axioms for Suslin and almost Suslin trees on guessing model properties. In particular, we prove that if <i>S</i> is a Suslin tree, then the axioms PFA(S) and PFA(S)[S] imply the Guessing Model Property and the Indestructible Guessing Model Property, respectively, and, if <i>T*</i> is an almost Suslin Aronszajn tree, then the axiom PFA(T*) implies the Indestructible Guessing Model Property. This answers a number of questions of Cox and Krueger.</p>