<p>Antimicrobial resistance (AMR), also known as antibiotic resistance, is a serious health issue that impacts both human and animal populations. Many factors promote the onset and spread of AMR in coastal environments. These include sewage discharge, aquaculture, runoff, bacterial dispersal, climate change, and chemical pollutants. The distribution and prevalence of antibiotics and antibiotic resistance genes (ARGs) in coastal water systems are discussed with a focus on the implication of human health and the environment. The study highlights the frequency of antibiotics and ARG in different regions while summarizing the earlier research on estuarine and coastal areas. Addressing AMR issues in coastal waters effectively requires an integrated and cooperative strategy. Immediate action must be taken immediately to address the issue and put long-term solutions in place due to the growing threat of AMR in coastal waters. It is possible to prevent the spread of AMR, protect public health, and preserve the health of coastal ecosystems by using a collaborative and comprehensive strategy.</p>