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Background <p>Acromegaly is a multi-organ disorder characterized by the hypersecretion of growth hormone (GH). The phosphoinositide-3 kinase (PI3K) pathway regulates various cellular responses, including survival, growth, and cytoskeletal remodeling. This study aimed to evaluate influence of serum PI3K levels on elevated GH in patients with acromegaly.</p> Methods <p>In this case-control study, 60 patient’s diagnosis with acromegaly and 30 age-matched healthy individuals (control group) were enrolled. GH and IGF-1 levels were measured using a Roche kits on a Cobas e411 instrument. Other biochemical test (FBG, urea, creatinine, ALT, AST, and lipid profile) were performed using a Cobas c111 analyzer (Roche). Serum PI3K levels were quantified using an ELISA kit (BioSource, USA).</p> Results <p>The study included 60 acromegaly patients (mean age 53.93 ± 11.33 years, 25 female, 35 male and 30 healthy controls mean age 50.63 ± 6.45 years, 11 female, 19 male). Serum levels GH, IGF-1, and PI3K were significantly higher in acromegaly patients compared to the control group. A significant positive correlation was observed between PI3K and levels of IGF-1, GH, LDL, AST, and ALT within the acromegaly group. The Receiver Operating characteristic (ROC) curve analysis for PI3K as a diagnostic marker for acromegaly yielded a significantly area under the curve (AUC = 0.982, <i>p</i> &lt; 0.001), indicating high diagnostic reliability.</p> Conclusion <p>These findings indicate that serum PI3K levels are significantly elevated in patients with acromegaly and positively correlate with GH and IGF-1. The high diagnostic accuracy suggests that PIK3 could serve as a reliable biomarker for the diagnosis of acromegaly.</p>

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Exploring impact of the phosphoinositide-3 kinase on excess growth hormone in acromegaly patients

  • 期刊论文

  • 发表日期：

    2026年4月30日

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  • Baydaa Ahmed Abed,
  • Shatha Mohammed Jawad Al-Khateeb,
  • Noor Naeem Jasim,
  • Noor Ulhuda G. Mohammed,
  • Rand Jalal Abd Al-Ghanny,
  • Hussein Hatam Omran

摘要

Background

Acromegaly is a multi-organ disorder characterized by the hypersecretion of growth hormone (GH). The phosphoinositide-3 kinase (PI3K) pathway regulates various cellular responses, including survival, growth, and cytoskeletal remodeling. This study aimed to evaluate influence of serum PI3K levels on elevated GH in patients with acromegaly.

Methods

In this case-control study, 60 patient’s diagnosis with acromegaly and 30 age-matched healthy individuals (control group) were enrolled. GH and IGF-1 levels were measured using a Roche kits on a Cobas e411 instrument. Other biochemical test (FBG, urea, creatinine, ALT, AST, and lipid profile) were performed using a Cobas c111 analyzer (Roche). Serum PI3K levels were quantified using an ELISA kit (BioSource, USA).

Results

The study included 60 acromegaly patients (mean age 53.93 ± 11.33 years, 25 female, 35 male and 30 healthy controls mean age 50.63 ± 6.45 years, 11 female, 19 male). Serum levels GH, IGF-1, and PI3K were significantly higher in acromegaly patients compared to the control group. A significant positive correlation was observed between PI3K and levels of IGF-1, GH, LDL, AST, and ALT within the acromegaly group. The Receiver Operating characteristic (ROC) curve analysis for PI3K as a diagnostic marker for acromegaly yielded a significantly area under the curve (AUC = 0.982, p < 0.001), indicating high diagnostic reliability.

Conclusion

These findings indicate that serum PI3K levels are significantly elevated in patients with acromegaly and positively correlate with GH and IGF-1. The high diagnostic accuracy suggests that PIK3 could serve as a reliable biomarker for the diagnosis of acromegaly.