Background <p>Nicotine addiction is the most common and important type of substance addiction and has lots of harms to human health. The most important thing a smoker can do to protect their health is to quit smoking. When deciding to quit smoking, the relationships of a person with people he/she lives with also affect the quitting process positively or negatively.</p> Aim <p>The purpose of this study was to define the couple-burnout and professional burnout experienced by individuals who were applying to smoking cessation clinics for the first time.</p> Methods <p>The study was carried out at the Smoking Cessation Polyclinics. Participants were given a survey form that included questions about their sociodemographics and reasons for starting to smoke. Also “Modified Fagerstrom Test” “Burnout Scale short form,” and “Couple-burnout Scale-short form” were used. The statistical analysis was conducted using IBM SPSS Statistics for Windows, Version 23.</p> Results <p>People who were unhappy with their jobs (<i>p</i> = 0.035), worked shifts (<i>p</i> = 0.038), or suffered from mental illnesses (<i>p</i> = 0.005) had higher levels of burnout. Women are more likely than males to experience couple burnout (<i>p</i> = 0.001) and to be dissatisfied with their careers (<i>p</i> = 0.031). A significant positive connection (<i>p</i> &lt; 0.001) was found between the spouse burnout scale and the burnout scale.</p> Conclusion <p>In people who decide to quit smoking, the underlying burnout should definitely be taken into consideration. Spousal support should also be considered among other factors during polyclinic visits.</p>