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Backround <p>While low-carbohydrate/high-protein diets are common for rapid weight loss, their controversial side effects warrant investigation.</p> Aims <p> This study aimed to examine age- and duration-dependent effects of high-protein diets on the liver and kidneys of adult (6 months) and elderly (18 months) rats.</p> Methods <p> Thirty-two male Wistar albino rats were divided into four groups: Adult Standard, Adult High-Protein, Elderly Standard, and Elderly High-Protein. After one month, we collected kidney and liver samples for histological analysis and biochemical assessment of MDA and GSH levels.&#xa0;</p> Results <p> High-protein diets severely affected the kidneys of both adult and elderly rats. The livers also exhibited moderate degenerative changes. We found a significant increase in MDA levels, indicating lipid peroxidation. Additionally, hepatic and renal GSH levels significantly increased in elderly rats on a high-protein diet, suggesting a metabolic response to oxidative stress.&#xa0;</p> Conclusion <p> Our findings suggest that high-protein diets should be applied very cautiously, especially in elderly individuals and those with existing kidney disorders.</p>

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Age-related effects of high protein diet on rat liver and kidney

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月17日

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  • Fatma Helvacıoğlu,
  • Eda Özturan Özer,
  • Caner Çetinoğlu,
  • Pınar Ülgen,
  • Sera Kılıç,
  • Deniz Can Başaran,
  • Berk Yasin Ekenci,
  • Fırat Yıldırım,
  • Mustafa Agah Tekindal,
  • Attila Dağdeviren

摘要

Backround

While low-carbohydrate/high-protein diets are common for rapid weight loss, their controversial side effects warrant investigation.

Aims

This study aimed to examine age- and duration-dependent effects of high-protein diets on the liver and kidneys of adult (6 months) and elderly (18 months) rats.

Methods

Thirty-two male Wistar albino rats were divided into four groups: Adult Standard, Adult High-Protein, Elderly Standard, and Elderly High-Protein. After one month, we collected kidney and liver samples for histological analysis and biochemical assessment of MDA and GSH levels. 

Results

High-protein diets severely affected the kidneys of both adult and elderly rats. The livers also exhibited moderate degenerative changes. We found a significant increase in MDA levels, indicating lipid peroxidation. Additionally, hepatic and renal GSH levels significantly increased in elderly rats on a high-protein diet, suggesting a metabolic response to oxidative stress. 

Conclusion

Our findings suggest that high-protein diets should be applied very cautiously, especially in elderly individuals and those with existing kidney disorders.