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Background <p>Hyperemesis Gravidarum (HG) in pregnancy is a severe form of nausea and vomiting resulting in dehydration, weight loss and declining mental health. Research on the clinical characteristics and management of HG in Ireland is limited.</p> Aim <p>To describe a cohort of women with HG attending an Irish Maternity Hospital.</p> Methods <p>A retrospective chart review of 198 women referred for HG management in an urban stand-alone maternity hospital in Dublin between 2020-2023. Data included medical and obstetric history, management, symptoms and birth outcomes.</p> Results <p>Most (64.8%) were multiparous, with 77% reporting previous HG. The majority (76.3%) presented in the first trimester. PUQE scores indicated mild (3.4%), moderate (48.3%), or severe (48.3%) nausea and vomiting, and 72.1% rated their wellbeing 5 or lower (on a scale of 0-10). Mean weight loss from pre-pregnancy to first presentation was-2.64kg (SD 3.9), with 39% losing &gt;5%. Dehydration (61.3%) and ketonuria (42.8%) were common. Mean duration of HG care was 11.04 (SD 8.4) weeks. Nearly half (49.5%) trialled 3–4 medications, with 87.9% prescribed Doxylamine/Pyridoxine and/or Prochlorperazine. Hospital resource use was high; 76% required day ward management, 78% attended A&amp;E, and 36.9% needed overnight admission, at least once. Among 187 live births, 55.2% were male, 70% were vaginal deliveries, 9.1% were small for gestational age (&lt;10<sup>th</sup>centile) and 13.4% were large for gestational age (&gt;90<sup>th</sup>centile).</p> Conclusion <p>HG significantly impacts maternal health and places demands on hospital resources. While birthweight centiles were generally normal, HG’s potential long-term effects on child health warrant further investigation.</p>

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Clinical characteristics, management and outcomes of hyperemesis gravidarum: a retrospective study in an Irish maternity hospital

  • 期刊论文

  • 发表日期：

    2026年1月3日

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  • Jean Doherty,
  • Sarah Louise Killeen,
  • Lucille Sheehy,
  • Helen McHale,
  • Sinead Curran,
  • Melanie Bennett,
  • Suzanne Murphy,
  • Eileen O’Brien

摘要

Background

Hyperemesis Gravidarum (HG) in pregnancy is a severe form of nausea and vomiting resulting in dehydration, weight loss and declining mental health. Research on the clinical characteristics and management of HG in Ireland is limited.

Aim

To describe a cohort of women with HG attending an Irish Maternity Hospital.

Methods

A retrospective chart review of 198 women referred for HG management in an urban stand-alone maternity hospital in Dublin between 2020-2023. Data included medical and obstetric history, management, symptoms and birth outcomes.

Results

Most (64.8%) were multiparous, with 77% reporting previous HG. The majority (76.3%) presented in the first trimester. PUQE scores indicated mild (3.4%), moderate (48.3%), or severe (48.3%) nausea and vomiting, and 72.1% rated their wellbeing 5 or lower (on a scale of 0-10). Mean weight loss from pre-pregnancy to first presentation was-2.64kg (SD 3.9), with 39% losing >5%. Dehydration (61.3%) and ketonuria (42.8%) were common. Mean duration of HG care was 11.04 (SD 8.4) weeks. Nearly half (49.5%) trialled 3–4 medications, with 87.9% prescribed Doxylamine/Pyridoxine and/or Prochlorperazine. Hospital resource use was high; 76% required day ward management, 78% attended A&E, and 36.9% needed overnight admission, at least once. Among 187 live births, 55.2% were male, 70% were vaginal deliveries, 9.1% were small for gestational age (<10thcentile) and 13.4% were large for gestational age (>90thcentile).

Conclusion

HG significantly impacts maternal health and places demands on hospital resources. While birthweight centiles were generally normal, HG’s potential long-term effects on child health warrant further investigation.