Scholarlink

<p>This study reports the eco-friendly synthesis of TiO<sub>2</sub> and CeO<sub>2</sub> NPs using aqueous extract of <i>Senna</i> leaves and seeds as a natural reducing and stabilizing agent. The approach addresses the demand for sustainable multifunctional nanomaterials capable of removing pharmaceutical pollutants from water while exhibiting promising biomedical properties. Both NPs were successfully formed with small crystallite/particle sizes (less than 23&#xa0;nm, confirmed by XRD and TEM) and good colloidal stability (zeta potentials of approximately  − 25 mV to − 28&#xa0;mV). Comparative evaluation revealed that CeO<sub>2</sub> NPs outperformed TiO<sub>2</sub> in most tested applications. CeO<sub>2</sub> showed superior vancomycin adsorption (following pseudo-second-order kinetics and Langmuir isotherm, with a notable maximum capacity of 91.6 mg/g), significantly higher hydrogen peroxide scavenging and total antioxidant activity in a concentration-dependent manner, markedly stronger broad-spectrum antibacterial effects (inhibition zones up to 37&#xa0;mm against <i>Staphylococcus aureus</i> and 30&#xa0;mm against <i>Escherichia coli</i> at 1000&#xa0;µg/mL), and greater cytotoxicity against MCF-7 and Caco-2 cancer cell lines (IC<sub>50</sub> &lt;&#xa0;76&#xa0;µg/mL). These findings highlight the potential of green-synthesized CeO<sub>2</sub> NPs as versatile, high-performance agents for integrated environmental remediation and biomedical applications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Vancomycin Adsorption, Anti-oxidant, Antimicrobial, and Anticancer Properties of Green-Synthesized CeO2 and TiO2 NPs: A Comparative Study

  • 期刊论文

  • 发表日期：

    2026年3月6日

查看全文
  • Rana Akrum Saeed,
  • Shaimaa Muyasser Nayif,
  • Basima A. A. Saleem,
  • Nadia H. Mohamed,
  • Helal F. Hetta,
  • Sedky H. A. Hassan,
  • Mohammed S. Saddik,
  • Mohamed Ahmed,
  • Khaled Hassan,
  • Mostafa F. Al-Hakkani

摘要

This study reports the eco-friendly synthesis of TiO2 and CeO2 NPs using aqueous extract of Senna leaves and seeds as a natural reducing and stabilizing agent. The approach addresses the demand for sustainable multifunctional nanomaterials capable of removing pharmaceutical pollutants from water while exhibiting promising biomedical properties. Both NPs were successfully formed with small crystallite/particle sizes (less than 23 nm, confirmed by XRD and TEM) and good colloidal stability (zeta potentials of approximately  − 25 mV to − 28 mV). Comparative evaluation revealed that CeO2 NPs outperformed TiO2 in most tested applications. CeO2 showed superior vancomycin adsorption (following pseudo-second-order kinetics and Langmuir isotherm, with a notable maximum capacity of 91.6 mg/g), significantly higher hydrogen peroxide scavenging and total antioxidant activity in a concentration-dependent manner, markedly stronger broad-spectrum antibacterial effects (inhibition zones up to 37 mm against Staphylococcus aureus and 30 mm against Escherichia coli at 1000 µg/mL), and greater cytotoxicity against MCF-7 and Caco-2 cancer cell lines (IC50 < 76 µg/mL). These findings highlight the potential of green-synthesized CeO2 NPs as versatile, high-performance agents for integrated environmental remediation and biomedical applications.