<p>To address the brittleness limitation of the W-Zr binary alloy system at the end of damage, this study successfully prepared a new W₃₅Zr₃₅Ti₁₅Nb₁₅ refractory high-entropy alloy (W-RHEA) sample by introducing Ti-Nb elements and using vacuum arc melting technology. To investigate the mechanical-chemical coupling behavior under impact loading, the microscopic morphology and quasi-static and dynamic mechanical responses were evaluated, along with the constitutive model and energy-release characteristics. The results show that the W/Ti_xW_y and Nb_x/Ti_xZr_y BCC solid solution phases replaced the original W₂Zr brittle phase, and the two-phase structure exhibited a significant positive strain rate-strengthening effect. The critical fracture strain first increased and then decreased with the strain rate, and there were significant differences in energy release at different strain rates. When the strain rate was &gt; 3135&#xa0;s⁻¹, the material showed shear cracks and local reactions, and the best strength-plasticity-chemical balance effect was observed in the strain rate range of 3135 to 3931&#xa0;s⁻¹. The improved Johnson-Cook (J-C) model accurately described the alloy’s thermodynamic and dynamic flow behavior. Significant slip occurred in the direction of the maximum shear force during the impact compression, eventually leading to fracture failure. Zr was the primary reactive component reacting with air, and the “molten droplets” observed in the reaction products demonstrated the alloy’s excellent plasticity.</p>