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<p>Currently, bone tissue repair has emerged as a critical medical priority worldwide, largely due to the rising human life expectancy. Although bone grafting remains the standard treatment, it faces sustainability challenges and is often associated with complications such as infections, which can require further surgery or, in severe cases, lead to amputation. To address these issues, researchers are increasingly focusing on biodegradable scaffolds that support tissue regeneration by promoting cellular differentiation. This study aims to enhance the cellular response of a porous scaffold designed through 3D printing. Using a wire deposition modeling approach, we developed cylindrical scaffolds with triangular pores. Then, a vinylbenzylphosphonic acid monomer was polymerized and covalently anchored as poly(vinyl benzyl phosphonic acid) onto the scaffold surface through a two-step UV irradiation grafting process. Characterization techniques, including colorimetric assays and infrared spectroscopy, confirmed the successful poly(vinyl benzyl phosphonic acid) deposition onto the sample surface. Furthermore, scanning electron microscopy, size exclusion chromatography and differential scanning calorimetry further validated that the fabrication and grafting processes, maintening the structural integrity and intrinsic properties of the implants. Finally, cell viability assays revealed improved survival rates of MC3T3-E1 pre-osteoblasts, while mineralization assays indicated enhanced and accelerated cellular differentiation with the effect of porous scaffold and post-grafting.</p>

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Enhancing Osseointegration Properties Through Bioactivation of a PCL Porous Scaffold Fabricated via Fused Deposition Modeling Process

  • 期刊论文

  • 发表日期：

    2025年5月21日

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  • Gabriel Roulhac De Rochebrune,
  • Jean-Sébastien Baumann,
  • Marc Lecouvey,
  • Thibaut Legigan,
  • Julia Deschamp,
  • Céline Falentin-Daudré

摘要

Currently, bone tissue repair has emerged as a critical medical priority worldwide, largely due to the rising human life expectancy. Although bone grafting remains the standard treatment, it faces sustainability challenges and is often associated with complications such as infections, which can require further surgery or, in severe cases, lead to amputation. To address these issues, researchers are increasingly focusing on biodegradable scaffolds that support tissue regeneration by promoting cellular differentiation. This study aims to enhance the cellular response of a porous scaffold designed through 3D printing. Using a wire deposition modeling approach, we developed cylindrical scaffolds with triangular pores. Then, a vinylbenzylphosphonic acid monomer was polymerized and covalently anchored as poly(vinyl benzyl phosphonic acid) onto the scaffold surface through a two-step UV irradiation grafting process. Characterization techniques, including colorimetric assays and infrared spectroscopy, confirmed the successful poly(vinyl benzyl phosphonic acid) deposition onto the sample surface. Furthermore, scanning electron microscopy, size exclusion chromatography and differential scanning calorimetry further validated that the fabrication and grafting processes, maintening the structural integrity and intrinsic properties of the implants. Finally, cell viability assays revealed improved survival rates of MC3T3-E1 pre-osteoblasts, while mineralization assays indicated enhanced and accelerated cellular differentiation with the effect of porous scaffold and post-grafting.