<p>The effect of rolling on the microstructural, mechanical, and damping properties of an as-cast WE43 alloy has been investigated. The microstructure was analyzed using a combination of methods, including optical microscopy (OM), scanning electron microscopy (SEM), X-ray diffraction (XRD), and transmission electron microscopy (TEM). The mechanical properties were assessed utilizing a universal testing machine and a hardness tester. The damping properties were estimated by means of a dynamic mechanical analyzer. The results revealed that rolling significantly reduced the grain size in the as-cast WE43 alloy. The irregular eutectic structure was broken into finely dispersed phase particles. Long-chain-shaped intermetallic compounds were distributed along the rolling direction within the matrix. These microstructural changes led to significant improvements in the mechanical properties of the as-cast alloy. However, the increase in grain boundary area, the number of second-phase particles, and dislocation density after rolling introduces complex interactions that affect the damping performance. On the one hand, an increase in grain boundary area and number of second phase particles hindered dislocation movement. On the other hand, severe deformation introduced new dislocations. This led to an increase in density of mobile dislocations.</p>