Early Detection and Personalized Risk Assessment of Breast Cancer: An Integrative Review and Comparative Evaluation of AI Models Using Clinical and Imaging Data
摘要
Breast cancer remains a leading cause of cancer-related mortality among women worldwide, underscoring the urgency for early and accurate detection strategies. While traditional research has primarily emphasized mammography and binary classification tasks, emerging advances in artificial intelligence (AI) now enable integration of multimodal data, multi-class severity assessment, and enhanced interpretability. In this review, we synthesize the existing literature on AI-driven approaches for breast cancer detection and risk prediction, and complement it with an empirical comparative evaluation across clinical data, ultrasound, and computed tomography imaging. Both traditional machine learning classifiers and deep learning architectures are examined, with ensemble and transfer learning methods demonstrating superior diagnostic accuracy. Additionally, text-based models provide valuable granularity in severity classification, and explainable AI (XAI) techniques such as Grad-CAM enhance transparency by generating interpretable visual insights. Together, these findings highlight the potential of hybrid and explainable AI systems to improve precision, reliability, and clinical applicability in breast cancer management. By integrating a broad review with comparative analysis, this work provides an evidence-based perspective on current advances, limitations, and future directions toward personalized and trustworthy AI solutions in oncology.