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<p>The sustainable utilization of marine bioresources has emerged as a promising strategy to develop high-value products for nutraceutical and biotechnological applications, offering an alternative to conventional petroleum-based industries. However, their industrial application remains limited by inefficient extraction processes, which are typically energy-intensive and unsustainable. In this study, a biorefining approach with optimized green extraction was developed using the marine microalga <i>Dunaliella tertiolecta</i> as a model biomass, with lutein as the extraction target. Ethanol, recognized for its extraction efficiency and environmental safety, was selected as the green solvent. The extraction process was statistically optimized to maximize lutein recovery, with the optimal conditions determined as 25&#xa0;°C, 5.0&#xa0;h reaction time, and 93.3&#xa0;g/L solid loading. The antioxidant activities of the lutein-containing extract obtained under these conditions were determined as follows: ABTS IC<sub>50</sub> of 4.4&#xa0;μg/mL, SOD IC<sub>50</sub> of 9.3&#xa0;μg/mL, and FRAP of 7622.9&#xa0;μmol/L. Mass balance analysis confirmed that optimized extraction conditions improved lutein recovery by 2.4-fold, yielding 83.0&#xa0;g from 1000&#xa0;g of <i>D. tertiolecta</i>. This study highlights the potential of optimized green solvent-based extraction for scalable lutein production, supporting sustainable biorefining and nutraceutical applications.</p>

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Optimization of Green Solvent-Based Extraction to Improve Lutein Recovery from Dunaliella tertiolecta Targeting Nutraceutical Applications

  • 期刊论文

  • 发表日期：

    2025年9月14日

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  • Kang Hyun Lee,
  • Han-Sol Kim,
  • Hyunjun Park,
  • Jang-Seu Ki,
  • Hah Young Yoo

摘要

The sustainable utilization of marine bioresources has emerged as a promising strategy to develop high-value products for nutraceutical and biotechnological applications, offering an alternative to conventional petroleum-based industries. However, their industrial application remains limited by inefficient extraction processes, which are typically energy-intensive and unsustainable. In this study, a biorefining approach with optimized green extraction was developed using the marine microalga Dunaliella tertiolecta as a model biomass, with lutein as the extraction target. Ethanol, recognized for its extraction efficiency and environmental safety, was selected as the green solvent. The extraction process was statistically optimized to maximize lutein recovery, with the optimal conditions determined as 25 °C, 5.0 h reaction time, and 93.3 g/L solid loading. The antioxidant activities of the lutein-containing extract obtained under these conditions were determined as follows: ABTS IC50 of 4.4 μg/mL, SOD IC50 of 9.3 μg/mL, and FRAP of 7622.9 μmol/L. Mass balance analysis confirmed that optimized extraction conditions improved lutein recovery by 2.4-fold, yielding 83.0 g from 1000 g of D. tertiolecta. This study highlights the potential of optimized green solvent-based extraction for scalable lutein production, supporting sustainable biorefining and nutraceutical applications.