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<p>Polydimethylsiloxane (PDMS) microparticles exhibit significant potential for biomedical applications owing to their biocompatibility, chemical inertness, transparency, and ease of soft lithography-based fabrication. However, their high viscosity and hydrophobicity make it difficult to use them in the form of particles in aqueous environments. In this study, we present a novel and efficient methodology for fabricating uniform PDMS microparticles using a discontinuous dewetting (DD) technique. Our approach employs a polyethylene glycol diacrylate mold coated with a superhydrophobic layer, enabling DD over a broad viscosity range and achieving highly monodisperse particle production. To utilize them in an aqueous solution, we implemented two surface modification strategies: a bovine serum albumin (BSA) treatment, and the formation of “hydrogel skin”. Such strategies enhance their water wettability and the particle’s dispersion in an aqueous solution. Our findings demonstrate the successful fabrication of monodisperse PDMS microparticles with diameters ranging from 200 to 1000&#xa0;μm, which were well dispersed in organic or aqueous solutions. Our research would suggest a new strategy for how to use PDMS in bioengineering. We anticipate that our PDMS microparticles offer significant potential in diagnostic, chemotaxis, and therapeutic applications.</p>

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Discontinuous Dewetting-Based Synthesis of Monodisperse Polydimethylsiloxane Microparticles with Tunable Aqueous Dispersibility via Surface Engineering

  • 期刊论文

  • 发表日期：

    2025年6月20日

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  • Chan Woo Park,
  • Yunkyeong Cho,
  • Jae Jung Kim

摘要

Polydimethylsiloxane (PDMS) microparticles exhibit significant potential for biomedical applications owing to their biocompatibility, chemical inertness, transparency, and ease of soft lithography-based fabrication. However, their high viscosity and hydrophobicity make it difficult to use them in the form of particles in aqueous environments. In this study, we present a novel and efficient methodology for fabricating uniform PDMS microparticles using a discontinuous dewetting (DD) technique. Our approach employs a polyethylene glycol diacrylate mold coated with a superhydrophobic layer, enabling DD over a broad viscosity range and achieving highly monodisperse particle production. To utilize them in an aqueous solution, we implemented two surface modification strategies: a bovine serum albumin (BSA) treatment, and the formation of “hydrogel skin”. Such strategies enhance their water wettability and the particle’s dispersion in an aqueous solution. Our findings demonstrate the successful fabrication of monodisperse PDMS microparticles with diameters ranging from 200 to 1000 μm, which were well dispersed in organic or aqueous solutions. Our research would suggest a new strategy for how to use PDMS in bioengineering. We anticipate that our PDMS microparticles offer significant potential in diagnostic, chemotaxis, and therapeutic applications.