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<p><i>Bacillus velezensis</i>, with the ability to produce a variety of antimicrobial compounds, has great application prospects in the fields of food and agriculture. In this work, a novel strain <i>B. velezensis</i> OUC-BV1 was screened and identified. Whole genome prospecting of OUC-BV1 revealed that as high as four gene clusters involved in the synthesis of antimicrobial lipopeptides were discovered, indicating a substantial capacity for manufacture of antimicrobial compounds with good antibacterial efficacy. After separation, seven types of lipopeptides with wide antimicrobial spectrum were harvested, which can effectively inhibit the growth of <i>Escherichia coli</i> as well as aquatic pathogens such as <i>Vibrio harveyi, Aeromonas vibrio</i>, and <i>Aeromonas hydrophila</i>. The purified lipopeptides, especially C<sub>15</sub> bacillomycin D, had MIC values ranging from 8 to 64 µg/mL with good temperature and gastrointestinal environment stability. <i>B. velezensis</i> OUC-BV1 is a promising and potent strain producing a variety of antimicrobial compounds with wide antimicrobial spectrum and excellent stability.</p>

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Extraction and Identification of Antimicrobial Compounds from Novel Bacillus velezensis OUC-BV1 Guided by Genome Prospecting

  • 期刊论文

  • 发表日期：

    2026年5月22日

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  • Yongzhen Wang,
  • Gefei Dong,
  • Xinna Zuo,
  • Zhe Wang,
  • Yue Li,
  • Xin Gao,
  • Xiangzhao Mao,
  • Hong Jiang

摘要

Bacillus velezensis, with the ability to produce a variety of antimicrobial compounds, has great application prospects in the fields of food and agriculture. In this work, a novel strain B. velezensis OUC-BV1 was screened and identified. Whole genome prospecting of OUC-BV1 revealed that as high as four gene clusters involved in the synthesis of antimicrobial lipopeptides were discovered, indicating a substantial capacity for manufacture of antimicrobial compounds with good antibacterial efficacy. After separation, seven types of lipopeptides with wide antimicrobial spectrum were harvested, which can effectively inhibit the growth of Escherichia coli as well as aquatic pathogens such as Vibrio harveyi, Aeromonas vibrio, and Aeromonas hydrophila. The purified lipopeptides, especially C15 bacillomycin D, had MIC values ranging from 8 to 64 µg/mL with good temperature and gastrointestinal environment stability. B. velezensis OUC-BV1 is a promising and potent strain producing a variety of antimicrobial compounds with wide antimicrobial spectrum and excellent stability.