<p>The geological structure in the Leiwuqi-Zuogong area of Tibet is complex, with abundant outcropping strata and frequent magmatic activities, providing a favorable metallogenic background for iron-copper polymetallic deposits and demonstrating significant prospecting potential. However, the high-altitude and deeply incised topography in the study area has made traditional ground geological exploration difficult and costly to implement. This study aims to utilize the latest measured aero-magnetic data and apply a combination of geophysical techniques, including Euler deconvolution, tilt derivative, and gradient magnitude, to process the aero-magnetic data. By analyzing the geological genesis of the aero-magnetic field and interpreting the fault structures controlling magmatism and mineralization, this study deepens the understanding of the ore-controlling role of regional structures and constructs a trinity metallogenic prediction model of “structure-magmatism-stratigraphy”. The research clarifies the relationship between fault structures and mineral resources, providing a direction for subsequent exploration of iron-copper metal mineral resources in the Leiwuqi-Zuogong area of Tibet, and offering geological-geophysical evidence for the study of tectonic evolution on the Qinghai-Tibet Plateau.</p>