Purpose <p>Among the over 3.5 million prostate cancer survivors in the United States, prostate cancer is frequently diagnosed cancer among Latino men. Latino cancer survivors are more likely to experience poorer quality of life than White survivors. However, limited research has explored quality of life disparities between Latino and White prostate cancer survivors. Hence, we aimed to assess the health-related quality of life between a cohort of Latino and White men with prostate cancer.</p> Methods <p>We used survey data from participants in the UCLA Men’s Health Study between 2001 and 2018. Independent t-tests and multivariable linear regressions were used to assess quality of life, both general and prostate-cancer specific between Latino and White men at program enrollment.</p> Results <p>Our sample included 291 Latino men and 65 non-Latino White men. In multivariable linear models, general health (<i>β</i> = -7.93, <i>p</i> &lt; 0.01) and sexual bother (<i>β</i> = -14.33, <i>p</i> &lt; 0.05) remained significantly worse among Latino men than White men after controlling for age, relationship status, education, income, comorbidities, Gleason grade group, and primary treatment.</p> Conclusions <p>Latino men with prostate cancer reported poorer quality of life, particularly in the domains of general health and sexual bother compared to White men.</p> Implications for Cancer Survivors <p>Findings highlight the need for survivorship care that addresses Latino prostate survivors’ unique needs including general health and sexual bother.</p>