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Background <p>Black breast cancer (BC) survivors face a disproportionately high burden of obesity, which may detrimentally impact health-related quality of life (QoL). This study examines the relationship between various adiposity measures—body mass index (BMI), waist circumference, waist-to-hip ratio (WHR), percentage body fat (BF), and fat mass index (FMI)—and QoL in Black BC survivors participating in the Women’s Circle of Health Follow-Up Study, a New Jersey-based population cohort.</p> Methods <p>We analyzed data from 785 women aged 20–75, diagnosed with BC between 2012 and 2019. Participants completed interviews approximately 10&#xa0;months (visit 1) and 24&#xa0;months (visit 2) post-diagnosis. Adiposity measures were recorded at visit 1, while QoL was evaluated at visit 2 using the Functional Assessment of Cancer Therapy–Breast (FACT-B) overall score and subscales (physical, emotional, functional, social well-being, and BC-specific subscale). Multivariable robust Poisson regression models were used to estimate risk ratios for the association between adiposity and QoL, dichotomized as low/high based on sample medians.</p> Results <p>High levels of general and central obesity were prevalent (58% and 75%, respectively). Women with BMI ≥ 40&#xa0;kg/m<sup>2</sup> had a 54% higher risk of lower overall QoL compared to those with BMI 18.5–24.9 (RR, 1.54; 95% CI, 1.19–2.00). Elevated risk of low QoL was also observed for higher quartiles of waist circumference, BF, and FMI, primarily in physical well-being and BC-specific subscales.</p> Conclusion <p>Higher adiposity is significantly associated with lower QoL among Black BC survivors.</p> Implications for Cancer Survivors <p>Maintaining a healthy weight may support long-term QoL in Black BC survivors.&#xa0;</p>

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Prospective associations of adiposity with health-related quality of life during breast cancer survivorship among Black women

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月6日

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  • Carola T. Sánchez-Díaz,
  • Bo Qin,
  • Nur Zeinomar,
  • Hari S. Iyer,
  • Marley Perlstein,
  • Karen S. Pawlish,
  • Kitaw Demissie,
  • Chi-Chen Hong,
  • Elisa V. Bandera

摘要

Background

Black breast cancer (BC) survivors face a disproportionately high burden of obesity, which may detrimentally impact health-related quality of life (QoL). This study examines the relationship between various adiposity measures—body mass index (BMI), waist circumference, waist-to-hip ratio (WHR), percentage body fat (BF), and fat mass index (FMI)—and QoL in Black BC survivors participating in the Women’s Circle of Health Follow-Up Study, a New Jersey-based population cohort.

Methods

We analyzed data from 785 women aged 20–75, diagnosed with BC between 2012 and 2019. Participants completed interviews approximately 10 months (visit 1) and 24 months (visit 2) post-diagnosis. Adiposity measures were recorded at visit 1, while QoL was evaluated at visit 2 using the Functional Assessment of Cancer Therapy–Breast (FACT-B) overall score and subscales (physical, emotional, functional, social well-being, and BC-specific subscale). Multivariable robust Poisson regression models were used to estimate risk ratios for the association between adiposity and QoL, dichotomized as low/high based on sample medians.

Results

High levels of general and central obesity were prevalent (58% and 75%, respectively). Women with BMI ≥ 40 kg/m2 had a 54% higher risk of lower overall QoL compared to those with BMI 18.5–24.9 (RR, 1.54; 95% CI, 1.19–2.00). Elevated risk of low QoL was also observed for higher quartiles of waist circumference, BF, and FMI, primarily in physical well-being and BC-specific subscales.

Conclusion

Higher adiposity is significantly associated with lower QoL among Black BC survivors.

Implications for Cancer Survivors

Maintaining a healthy weight may support long-term QoL in Black BC survivors.