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<p><i>Bacillus safensis</i> is a Gram-positive, spore-forming, motile, mesophilic, and chemoheterotrophic bacterium renowned for its adaptability to a wide array of stringent environments, including spacecraft assembly facilities, saline deserts, and heavy metal-contaminated soils. Originally identified as a persistent contaminant, its unique physiological and genomic characteristics have positioned it as a promising candidate for diverse biotechnological applications. In 2015, we published the first review on the basic biology and biotechnological potentials of the bacterium, and we documented its first reference in producing keratinase through degradation of poultry feather, and its abilities to synthesize metal and metal alloy nanoparticles amidst several other applications. Since then, several new applications have emerged on the bacterium, including a US patent for <i>B. safensis-</i>based biofertilizer, thereby necessitating a renewed documentation on the fascinating bacterium—detailing current knowledge on the biology, ecology, and multifaceted applications of <i>B. safensis</i>, highlighting its potential as a plant growth-promoting rhizobacterium, a formidable biocontrol agent against phytopathogens, a producer of valuable industrial enzymes, and an effective tool for bioremediation, and production of secondary metabolites. Genomic and experimental analyses revealed its capacity to synthesize many bioactive compounds alongside exhibiting robust stress response systems. Future investigations on <i>B. safensis</i> should involve leveraging advanced molecular techniques for strain improvement, exploration of bioinformatic tools to reveal its metabolome, enhancement of its safety profile, and expansion of its application in sustainable agriculture and environmental management.</p>

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Bacillus safensis as a viable biotechnological tool: current trends and future prospects

  • 期刊论文

  • 发表日期：

    2026年5月8日

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  • Agbaje Lateef,
  • Isiaka Adedayo Adelere,
  • Zainab Oluwaranti Hammed

摘要

Bacillus safensis is a Gram-positive, spore-forming, motile, mesophilic, and chemoheterotrophic bacterium renowned for its adaptability to a wide array of stringent environments, including spacecraft assembly facilities, saline deserts, and heavy metal-contaminated soils. Originally identified as a persistent contaminant, its unique physiological and genomic characteristics have positioned it as a promising candidate for diverse biotechnological applications. In 2015, we published the first review on the basic biology and biotechnological potentials of the bacterium, and we documented its first reference in producing keratinase through degradation of poultry feather, and its abilities to synthesize metal and metal alloy nanoparticles amidst several other applications. Since then, several new applications have emerged on the bacterium, including a US patent for B. safensis-based biofertilizer, thereby necessitating a renewed documentation on the fascinating bacterium—detailing current knowledge on the biology, ecology, and multifaceted applications of B. safensis, highlighting its potential as a plant growth-promoting rhizobacterium, a formidable biocontrol agent against phytopathogens, a producer of valuable industrial enzymes, and an effective tool for bioremediation, and production of secondary metabolites. Genomic and experimental analyses revealed its capacity to synthesize many bioactive compounds alongside exhibiting robust stress response systems. Future investigations on B. safensis should involve leveraging advanced molecular techniques for strain improvement, exploration of bioinformatic tools to reveal its metabolome, enhancement of its safety profile, and expansion of its application in sustainable agriculture and environmental management.