Scholarlink

<p>Nanotechnology has emerged as a highly interdisciplinary field integrating physics, chemistry, biology, materials science, and medicine, enabling nanoscale innovations that impact healthcare, environmental science, and materials engineering. This work reports the hydrothermal-assisted synthesis of pure tin sulfide (SnS) and strontium-doped tin sulfide (Sr-SnS) nanoflowers. Structural and optical analyses were conducted using X-ray diffraction (XRD), scanning electron microscopy (SEM), and UV–visible spectroscopy (UV–Vis). The antimicrobial, antibiofilm, and antioxidant capabilities of both nanostructures were systematically evaluated through in vitro assays. Antibacterial activity was tested against Gram-positive bacteria (<i>Bacillus subtilis ATCC 6633, Staphylococcus aureus, Enterococcus faecalis</i>) and Gram-negative bacteria (<i>Escherichia coli, Klebsiella pneumoniae,</i> and <i>Acinetobacter baumannii</i>). Sr-SnS nanoflowers exhibited significantly lower minimum inhibitory concentrations (MICs) at 3.906&#xa0;μg/mL (<i>Bacillus subtilis</i>), 0.976&#xa0;μg/mL (<i>Staphylococcus aureus, Enterococcus faecalis</i>), 7.81&#xa0;μg/mL (<i>Escherichia coli</i>), 15.625&#xa0;μg/mL (<i>Klebsiella pneumoniae</i>), and 0.976&#xa0;μg/mL (<i>Acinetobacter baumannii</i>), whereas SnS nanoparticles had considerably higher MICs ranging from 125 to 250&#xa0;μg/mL. At concentrations of 25 and 50&#xa0;μg/mL, Sr-SnS nanoparticles demonstrated strong antibiofilm inhibition rates of 70.62 to75.48% (<i>Staphylococcus aureus</i>), 76.4 to 87.69% (<i>Candida albicans</i>), and 70.29 to 76.47% (<i>Pseudomonas aeruginosa</i>), surpassing those of SnS. Antioxidant assays (DPPH and FRAP) showed the Sr-SnS nanoflowers had an IC50 of 432.77&#xa0;μg/mL, nearly matching ascorbic acid (428.13&#xa0;μg/mL), with reducing power comparable to ascorbic acid and superior to SnS. These findings demonstrate that Sr-doped SnS nanoflowers exhibit exceptional antimicrobial, antibiofilm, and antioxidant properties, with promising potential applications in pharmaceutical and cosmetic industries.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Synthesis, characterization, and study of the potential bioactivity of Sr-doped SnS nanoflowers

  • 期刊论文

  • 发表日期：

    2026年1月23日

查看全文
  • Tayeb Bouarroudj,
  • Youcef Messai,
  • Djahida Lerari,
  • Nabil Bouarra,
  • Amira Bourouba,
  • Amina Bourouba,
  • Houneida Benbouzid,
  • Aziez Siham,
  • Khaldoune Bachari

摘要

Nanotechnology has emerged as a highly interdisciplinary field integrating physics, chemistry, biology, materials science, and medicine, enabling nanoscale innovations that impact healthcare, environmental science, and materials engineering. This work reports the hydrothermal-assisted synthesis of pure tin sulfide (SnS) and strontium-doped tin sulfide (Sr-SnS) nanoflowers. Structural and optical analyses were conducted using X-ray diffraction (XRD), scanning electron microscopy (SEM), and UV–visible spectroscopy (UV–Vis). The antimicrobial, antibiofilm, and antioxidant capabilities of both nanostructures were systematically evaluated through in vitro assays. Antibacterial activity was tested against Gram-positive bacteria (Bacillus subtilis ATCC 6633, Staphylococcus aureus, Enterococcus faecalis) and Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii). Sr-SnS nanoflowers exhibited significantly lower minimum inhibitory concentrations (MICs) at 3.906 μg/mL (Bacillus subtilis), 0.976 μg/mL (Staphylococcus aureus, Enterococcus faecalis), 7.81 μg/mL (Escherichia coli), 15.625 μg/mL (Klebsiella pneumoniae), and 0.976 μg/mL (Acinetobacter baumannii), whereas SnS nanoparticles had considerably higher MICs ranging from 125 to 250 μg/mL. At concentrations of 25 and 50 μg/mL, Sr-SnS nanoparticles demonstrated strong antibiofilm inhibition rates of 70.62 to75.48% (Staphylococcus aureus), 76.4 to 87.69% (Candida albicans), and 70.29 to 76.47% (Pseudomonas aeruginosa), surpassing those of SnS. Antioxidant assays (DPPH and FRAP) showed the Sr-SnS nanoflowers had an IC50 of 432.77 μg/mL, nearly matching ascorbic acid (428.13 μg/mL), with reducing power comparable to ascorbic acid and superior to SnS. These findings demonstrate that Sr-doped SnS nanoflowers exhibit exceptional antimicrobial, antibiofilm, and antioxidant properties, with promising potential applications in pharmaceutical and cosmetic industries.