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<p>The intestinal microbiota plays a significant role in metabolic regulation, and <i>Lactobacillus acidophilus</i> has shown potential as an inhibitor of insulin resistance, a key factor in Type 2 diabetes mellitus (T2DM). This study investigates the modulation of <i>L. acidophilus</i> adhesion power (AP) and biofilm productivity (BP) under the influence of exopolysaccharides (EPS) extracted from <i>Prevotella intermedia</i> strains, specifically the high EPS-producing S4 strain, sourced from children's oral gums. EPS concentrations ranged from 0.79 ± 0.03&#xa0;mg/mL to 0.65 ± 0.07&#xa0;mg/mL, and their effects on <i>L. acidophilus</i> were assessed in vitro. The results revealed a clear correlation between EPS concentration and both AP and BP. At 50&#xa0;µg/mL, the average AP and BP were 27.92 ± 1.7% and 30.99 ± 1.88%, respectively, while at 1.56&#xa0;µg/mL, these values decreased significantly to 0.56 ± 0.1% and 0.62 ± 0.11%. The highest EPS concentration notably enhanced <i>L. acidophilus</i> adhesion and biofilm formation, suggesting that EPS plays a crucial role in bacterial colonization and persistence within the gut. These findings underscore the potential of EPS as a modulator of microbial functions, supporting <i>L. acidophilus</i> in exerting beneficial effects on the intestinal microbiota. The study highlights the importance of EPS in strengthening the probiotic properties of <i>L. acidophilus</i>, potentially contributing to the management of insulin resistance and the prevention of T2DM. This research provides valuable insights into the therapeutic potential of microbial interactions in regulating gut health and metabolic function.</p>

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Exopolysaccharides of Prevotella intermedia are a biochemical key to modulate Lactobacillus acidophilus intestinalis in type 2 diabetic patients

  • 期刊论文

  • 发表日期：

    2026年1月13日

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  • Bachir Bourroubey,
  • Naziha Zenati,
  • Amira Braika

摘要

The intestinal microbiota plays a significant role in metabolic regulation, and Lactobacillus acidophilus has shown potential as an inhibitor of insulin resistance, a key factor in Type 2 diabetes mellitus (T2DM). This study investigates the modulation of L. acidophilus adhesion power (AP) and biofilm productivity (BP) under the influence of exopolysaccharides (EPS) extracted from Prevotella intermedia strains, specifically the high EPS-producing S4 strain, sourced from children's oral gums. EPS concentrations ranged from 0.79 ± 0.03 mg/mL to 0.65 ± 0.07 mg/mL, and their effects on L. acidophilus were assessed in vitro. The results revealed a clear correlation between EPS concentration and both AP and BP. At 50 µg/mL, the average AP and BP were 27.92 ± 1.7% and 30.99 ± 1.88%, respectively, while at 1.56 µg/mL, these values decreased significantly to 0.56 ± 0.1% and 0.62 ± 0.11%. The highest EPS concentration notably enhanced L. acidophilus adhesion and biofilm formation, suggesting that EPS plays a crucial role in bacterial colonization and persistence within the gut. These findings underscore the potential of EPS as a modulator of microbial functions, supporting L. acidophilus in exerting beneficial effects on the intestinal microbiota. The study highlights the importance of EPS in strengthening the probiotic properties of L. acidophilus, potentially contributing to the management of insulin resistance and the prevention of T2DM. This research provides valuable insights into the therapeutic potential of microbial interactions in regulating gut health and metabolic function.