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<p>Every year, 550 million cases of foodborne diseases are reported worldwide, with <i>Salmonella enterica</i> ranking as the second leading cause of gastroenteritis. The epidemiological and public health significance of this pathogen has prompted extensive research into its infection mechanisms, virulence factors, and the corresponding host immune responses. Among the various animal models employed, the nematode <i>Caenorhabditis elegans</i> has emerged as a valuable system for studying enteric pathogens due to its experimental advantages. Investigations into the interaction between different <i>S. enterica</i> serotypes and <i>C. elegans</i> have not only allowed the characterization of gastroenteritis-like symptoms in the nematode but also facilitated the identification of previously unrecognized virulence-associated genes. Furthermore, these studies have elucidated key innate immune pathways involved in the host response, including the p38 mitogen-activated protein kinase (MAPK) pathway and the DAF-2/DAF-16 insulin-like signaling pathway, as well as other defense mechanisms.</p>

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The nematode Caenorhabditis elegans as a model for Salmonella enterica pathogenesis and virulence study

  • 期刊论文

  • 发表日期：

    2025年9月17日

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  • Flor Alexia Esquivel-Barriga,
  • Gerardo Vázquez-Marrufo,
  • Ma. Soledad Vázquez-Garcidueñas

摘要

Every year, 550 million cases of foodborne diseases are reported worldwide, with Salmonella enterica ranking as the second leading cause of gastroenteritis. The epidemiological and public health significance of this pathogen has prompted extensive research into its infection mechanisms, virulence factors, and the corresponding host immune responses. Among the various animal models employed, the nematode Caenorhabditis elegans has emerged as a valuable system for studying enteric pathogens due to its experimental advantages. Investigations into the interaction between different S. enterica serotypes and C. elegans have not only allowed the characterization of gastroenteritis-like symptoms in the nematode but also facilitated the identification of previously unrecognized virulence-associated genes. Furthermore, these studies have elucidated key innate immune pathways involved in the host response, including the p38 mitogen-activated protein kinase (MAPK) pathway and the DAF-2/DAF-16 insulin-like signaling pathway, as well as other defense mechanisms.