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<p>Bacterial quorum sensing (QS) is a cell density dependent communication system which controls the expression of genes regulating virulence mechanism, biofilm formation and many other activities of pathogenic bacteria. The increasing threat of antibiotic-resistant pathogens has intensified interest in alternative therapeutic strategies such as quorum quenching (QQ) which involves the disruption of QS mechanism. It has emerged as a promising approach for controlling infectious properties of bacterial pathogens by targeting their cell-to-cell communication mechanism without relying on conventional antibiotic treatment. QQ represents a novel strategy to control bacterial infections with potentially reduced selective pressure for resistance, as it targets communication pathways instead of bacterial viability. QQ enzymes can be the promising approach to control acyl homoserine lactone (AHL) regulated QS in pathogens. QQ enzymes such as lactonases, acylases, and oxidoreductases target AHL signalling molecules. These enzymes effectively inhibit QS-regulated activities. This review mainly highlights the mechanism and applications of enzyme based QQ against QS systems gram-negative bacteria and its potential to combat multi-drug- resistant pathogens addressing the global challenge of antibiotic resistance.</p>

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Targeting acyl homoserine lactone regulated quorum sensing by quorum quenching enzymes

  • 期刊论文

  • 发表日期：

    2025年7月31日

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  • Niranjan Prakashrao Patil,
  • Shital Nitin Shevate

摘要

Bacterial quorum sensing (QS) is a cell density dependent communication system which controls the expression of genes regulating virulence mechanism, biofilm formation and many other activities of pathogenic bacteria. The increasing threat of antibiotic-resistant pathogens has intensified interest in alternative therapeutic strategies such as quorum quenching (QQ) which involves the disruption of QS mechanism. It has emerged as a promising approach for controlling infectious properties of bacterial pathogens by targeting their cell-to-cell communication mechanism without relying on conventional antibiotic treatment. QQ represents a novel strategy to control bacterial infections with potentially reduced selective pressure for resistance, as it targets communication pathways instead of bacterial viability. QQ enzymes can be the promising approach to control acyl homoserine lactone (AHL) regulated QS in pathogens. QQ enzymes such as lactonases, acylases, and oxidoreductases target AHL signalling molecules. These enzymes effectively inhibit QS-regulated activities. This review mainly highlights the mechanism and applications of enzyme based QQ against QS systems gram-negative bacteria and its potential to combat multi-drug- resistant pathogens addressing the global challenge of antibiotic resistance.