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Objective <p>This study examined the risk factors of in-stent restenosis (ISR) group after saphenous vein grafts (SVGs) percutaneous coronary intervention.</p> Methods <p>From March 2007 to February 2021, we collected 385 cases of SVGs percutaneous coronary intervention at the Tehran heart center. Patients experiencing ischemic symptoms were examined during follow-ups by cardiologists, who recommended a second coronary artery angiography. On the basis of coronary artery angiography, the cases were classified as ISR group (n = 284) or non-ISR group (n = 101). The medical history, biochemical indicators, coronary artery lesion features, and stent characteristics were retrospectively evaluated. Using univariate and multivariable Cox regression, risk factors for ISR group have been discovered.</p> Results <p>SVG ISR group was verified in 284 of the total number of patients (73.8%). The median length of follow-up was 8.6&#xa0;years (95% CI = 7.1–10.0&#xa0;years). Lower body mass index (HR = 0.95, 95% CI = 0.92–0.98, <i>p</i> = 0.006), lower left ventricular ejection fraction (HR = 0.94, 95% CI = 0.91–0.99, <i>p</i> = 0.001), and longer stent length (HR = 1.03, 95% CI = 1.01–1.05, <i>p</i> = <i>0.002</i>), remained independently associated with ISR group after multivariable analysis.</p> Conclusion <p>Lower body mass index, lower left ventricular ejection fraction, and longer stent length are independent predictors of ISR group after SVGs percutaneous coronary intervention.</p>

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Risk factors associated with saphenous vein graft in-stent restenosis

  • 期刊论文

  • 发表日期：

    2026年5月30日

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  • Alireza Amirzadegan,
  • Reza Ebadi,
  • Hamid Khederlou,
  • Pouya Karami Dehkordi,
  • Zahra Karimi

摘要

Objective

This study examined the risk factors of in-stent restenosis (ISR) group after saphenous vein grafts (SVGs) percutaneous coronary intervention.

Methods

From March 2007 to February 2021, we collected 385 cases of SVGs percutaneous coronary intervention at the Tehran heart center. Patients experiencing ischemic symptoms were examined during follow-ups by cardiologists, who recommended a second coronary artery angiography. On the basis of coronary artery angiography, the cases were classified as ISR group (n = 284) or non-ISR group (n = 101). The medical history, biochemical indicators, coronary artery lesion features, and stent characteristics were retrospectively evaluated. Using univariate and multivariable Cox regression, risk factors for ISR group have been discovered.

Results

SVG ISR group was verified in 284 of the total number of patients (73.8%). The median length of follow-up was 8.6 years (95% CI = 7.1–10.0 years). Lower body mass index (HR = 0.95, 95% CI = 0.92–0.98, p = 0.006), lower left ventricular ejection fraction (HR = 0.94, 95% CI = 0.91–0.99, p = 0.001), and longer stent length (HR = 1.03, 95% CI = 1.01–1.05, p = 0.002), remained independently associated with ISR group after multivariable analysis.

Conclusion

Lower body mass index, lower left ventricular ejection fraction, and longer stent length are independent predictors of ISR group after SVGs percutaneous coronary intervention.