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Objective <p>Generally, lung cancer originating from interstitial pneumonia (IP) is considered more aggressive; however, lung cancer in patients with autoimmune disease (AD)-related IP (AD-IP) is not well documented. This study aimed to clarify surgical outcomes and the risk of postoperative acute exacerbation (AE) in patients with lung cancer associated with AD-IP.</p> Methods <p>We retrospectively reviewed patients with lung cancer who underwent surgery between January 2011 and March 2021. Clinicopathological characteristics, recurrence-free survival (RFS), overall survival (OS), and perioperative outcomes were compared according to the presence of IP with or without AD.</p> Results <p>Among 1281 patients with lung cancer, 61 (4.8%) had idiopathic interstitial pneumonia (IIP), 87 (6.8%) had AD without IP, and 26 (2.0%) had AD-IP. The 5-year RFS rates were 80.9% for patients without IIP or AD, compared with 48.0% for IIP, 76.1% for AD without IP, and 29.8% for AD-IP. The corresponding 5-year OS rates were 84.1%, 53.9%, 77.0%, and 34.5%. Patients with AD-IP were significantly younger (<i>P</i> = 0.001), were more often female (<i>P</i> &lt; 0.001), had a lower % vital capacity (<i>P</i> = 0.002), and more frequently received preoperative steroids (<i>P</i> &lt; 0.001). The overall incidence of AE among the 87 patients with IP was 10.3% (9/87): 9.8% (6/61) with IIP and 11.5% (3/26) with AD-IP, with no significant difference.</p> Conclusions <p>Lung cancer with AD-IP had a poor prognosis, as did lung cancer with IIP, and the frequency of postoperative AE of patients with AD-IP was as high as that in those with IIP.</p>

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Surgical outcomes of lung cancer associated with autoimmune disease-related interstitial pneumonia

  • 期刊论文

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  • 发表日期：

    2025年11月21日

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  • Gouji Toyokawa,
  • Haruaki Hino,
  • Takaki Akamine,
  • Mototsugu Shimokawa,
  • Masaaki Sato

摘要

Objective

Generally, lung cancer originating from interstitial pneumonia (IP) is considered more aggressive; however, lung cancer in patients with autoimmune disease (AD)-related IP (AD-IP) is not well documented. This study aimed to clarify surgical outcomes and the risk of postoperative acute exacerbation (AE) in patients with lung cancer associated with AD-IP.

Methods

We retrospectively reviewed patients with lung cancer who underwent surgery between January 2011 and March 2021. Clinicopathological characteristics, recurrence-free survival (RFS), overall survival (OS), and perioperative outcomes were compared according to the presence of IP with or without AD.

Results

Among 1281 patients with lung cancer, 61 (4.8%) had idiopathic interstitial pneumonia (IIP), 87 (6.8%) had AD without IP, and 26 (2.0%) had AD-IP. The 5-year RFS rates were 80.9% for patients without IIP or AD, compared with 48.0% for IIP, 76.1% for AD without IP, and 29.8% for AD-IP. The corresponding 5-year OS rates were 84.1%, 53.9%, 77.0%, and 34.5%. Patients with AD-IP were significantly younger (P = 0.001), were more often female (P < 0.001), had a lower % vital capacity (P = 0.002), and more frequently received preoperative steroids (P < 0.001). The overall incidence of AE among the 87 patients with IP was 10.3% (9/87): 9.8% (6/61) with IIP and 11.5% (3/26) with AD-IP, with no significant difference.

Conclusions

Lung cancer with AD-IP had a poor prognosis, as did lung cancer with IIP, and the frequency of postoperative AE of patients with AD-IP was as high as that in those with IIP.