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Objective <p>Postoperative inflammation can promote immunosuppression and cancer recurrence. The present study investigated the correlation between serum C-reactive protein (CRP) levels after minimally invasive esophagectomy and long-term patient outcomes with large scale of cases.</p> Methods <p>Data from 329 patients who underwent minimally invasive esophagectomy were analyzed. Serum CRP levels were measured from postoperative day (POD) 1 to 7, 10, and 14. Low and high CRP groups were stratified by the median CRP values for each POD. Overall survival (OS) was defined as the time from esophagectomy to patient death. Relapse-free survival (RFS) was defined as the time to disease relapse or death from other cause.</p> Results <p>The high CRP group on PODs 5–7 and 10 had a significantly lower OS rate than the low CRP group. The high CRP group on POD 6, 7, and 10 also had a significantly lower RFS rate than the low CRP group. A high CRP level on POD 7 was identified as an independent risk factor for poor OS/RFS. In contrast, preoperative CRP levels (before esophagectomy) were not identified as a risk factor for unfavorable OS/RFS. The high CRP group had a higher mortality rate from other diseases than the low CRP group (15.0% vs 8.9%). Secondary malignancies tended to be more frequent in the high CRP group than in the low CRP group (26.1% vs 6.3%).</p> Conclusion <p>Elevated CRP levels in the immediate postoperative period after minimally invasive esophagectomy, particularly on POD 7, were significantly associated with poor OS and RFS.</p>

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Prognostic significance of postoperative serum C-reactive protein levels after minimally invasive esophagectomy for esophageal cancer

  • 期刊论文

  • 发表日期：

    2025年10月14日

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  • Hirotaka Ishida,
  • Toshiaki Fukutomi,
  • Yusuke Taniyama,
  • Chiaki Sato,
  • Hiroshi Okamoto,
  • Yohei Ozawa,
  • Jun Takahashi,
  • Iku Sasaki-Higashimoto,
  • Michiaki Unno,
  • Takashi Kamei

摘要

Objective

Postoperative inflammation can promote immunosuppression and cancer recurrence. The present study investigated the correlation between serum C-reactive protein (CRP) levels after minimally invasive esophagectomy and long-term patient outcomes with large scale of cases.

Methods

Data from 329 patients who underwent minimally invasive esophagectomy were analyzed. Serum CRP levels were measured from postoperative day (POD) 1 to 7, 10, and 14. Low and high CRP groups were stratified by the median CRP values for each POD. Overall survival (OS) was defined as the time from esophagectomy to patient death. Relapse-free survival (RFS) was defined as the time to disease relapse or death from other cause.

Results

The high CRP group on PODs 5–7 and 10 had a significantly lower OS rate than the low CRP group. The high CRP group on POD 6, 7, and 10 also had a significantly lower RFS rate than the low CRP group. A high CRP level on POD 7 was identified as an independent risk factor for poor OS/RFS. In contrast, preoperative CRP levels (before esophagectomy) were not identified as a risk factor for unfavorable OS/RFS. The high CRP group had a higher mortality rate from other diseases than the low CRP group (15.0% vs 8.9%). Secondary malignancies tended to be more frequent in the high CRP group than in the low CRP group (26.1% vs 6.3%).

Conclusion

Elevated CRP levels in the immediate postoperative period after minimally invasive esophagectomy, particularly on POD 7, were significantly associated with poor OS and RFS.