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<p>The aim of this study was to assess the differences in the pattern of symptoms and their changes after a comprehensive palliative care treatment in older patients in comparison with adults, who were admitted to an acute palliative care unit (APCU). Patients were categorized into three age ranges: adults (&lt; 65&#xa0;years, group A), old (65–74&#xa0;years, group O), very old (75–84&#xa0;years, group OO). The following parameters were collected: general characteristics, recent anticancer treatments, on/off treatment, previous care setting, Edmonton Symptom Assessment Scale (ESAS) and the Memorial Delirium Assessment Scale (MDAS), opioid doses, expressed as oral morphine equivalents (OME). Five-hundred-and-twenty patients were surveyed. Older patients had a lower Karnofsky level, were discharged on-therapy in a lower number of cases, and had a lower overall survival. The age-related differences in pain and dyspnea intensities recorded at admission, were nullified after a comprehensive palliative care treatment. Lower doses of opioids were effective. The APCU’s consistency and the expertise of its team contributed to improved outcomes of the elderly.</p>

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Age differences in symptom burden of patients with advanced cancer admitted to an acute palliative care unit

  • 期刊论文

  • 发表日期：

    2026年4月9日

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  • Sebastiano Mercadante,
  • Yasmine Grassi,
  • Sofia Settepani,
  • Alessio Lo Cascio,
  • Alessandra Casuccio

摘要

The aim of this study was to assess the differences in the pattern of symptoms and their changes after a comprehensive palliative care treatment in older patients in comparison with adults, who were admitted to an acute palliative care unit (APCU). Patients were categorized into three age ranges: adults (< 65 years, group A), old (65–74 years, group O), very old (75–84 years, group OO). The following parameters were collected: general characteristics, recent anticancer treatments, on/off treatment, previous care setting, Edmonton Symptom Assessment Scale (ESAS) and the Memorial Delirium Assessment Scale (MDAS), opioid doses, expressed as oral morphine equivalents (OME). Five-hundred-and-twenty patients were surveyed. Older patients had a lower Karnofsky level, were discharged on-therapy in a lower number of cases, and had a lower overall survival. The age-related differences in pain and dyspnea intensities recorded at admission, were nullified after a comprehensive palliative care treatment. Lower doses of opioids were effective. The APCU’s consistency and the expertise of its team contributed to improved outcomes of the elderly.