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<p>Few data are available regarding the adherence to treatment guidelines in individuals with type 2 diabetes mellitus (T2DM) admitted to Internal Medicine Wards (IMW) while no information is available concerning the possible efficacy of an educational intervention aimed at improving adherence in this setting. To explore guidelines adherence and the associated impact on glycemic control in subjects with T2DM hospitalized in IMW before and after an educational intervention, we conducted a 3-phase, cluster-randomized, multicenter study. During Phase 1, we retrospectively collected data from patients with T2DM hospitalized for any cause in IMW for ≥5&#xa0;days. In Phase 2, an educational training, based on the method of the educational outreach visits (EOV), was developed in 36 out of the 54 centers involved. In Phase 3, conducted 6&#xa0;months after the training, we replicated the collection of data performed in Phase 1. Overall, we analyzed data from 1909 and 1662 individuals with T2DM during Phase 1 and Phase 3 of the study, respectively. No changes were observed in the difference between mean fasting glycemia levels at discharge <i>vs</i> at admission in Phase 3 comparing EOV vs NO EOV groups. A statistically significant increase in adherence to guidelines was observed from Phase 1 to Phase 3 and a trend toward higher adherence was detected when comparing the EOV and the no EOV groups. A structured educational intervention improves adherence to guidelines for managing T2DM in individuals admitted to IMW but has no effect on short-term glycemic control.</p>

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Management of subjects with type 2 diabetes hospitalized in internal medicine units: a cluster-randomized, multicenter study before and after an educational program

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月13日

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  • Antonio Ceriello,
  • Andrea Fontanella,
  • Tiziana Marcella Attardo,
  • Giampietro Beltramello,
  • Aldo Fierro,
  • Francesco Prattichizzo,
  • Valeria Pellegrini,
  • Maria Serena Fiore,
  • Ernesto De Menis,
  • Ada Maffettone,
  • Luigi Magnani,
  • Ruggero Pastorelli,
  • Francesco Ventrella,
  • Massimo Rondana,
  • Mauro Maurantonio,
  • Mauro Scanferlato,
  • Francesco Finizola,
  • Maria Antonia Salvia,
  • Riccardo Nevola,
  • Giorgia Prampolini,
  • Marco Laccetti,
  • Franco Mastroianni,
  • Fabio Cartabellotta,
  • Elisa Zagarrì,
  • Francesco Dentali,
  • Dario Manfellotto,
  • Massimo Alessandri,
  • Fabrizio Valleggi,
  • Giancarlo Antonucci,
  • Sabrina Piredda,
  • Sergio Antonio Berra,
  • Luca Perfetti,
  • Maria Francesca Bracale,
  • Maurizio Burattini,
  • Nicola Tarquinio,
  • Giuseppe Campagna,
  • Tommasina Giuliani,
  • Armando Pepe,
  • Maurizio Cavalleri,
  • Elena Bernero,
  • Chiara Martino,
  • Sabrina Cerci,
  • Antonella Leonardi,
  • Laura Durola,
  • Paolo Corradini,
  • Daniela Sbocchia,
  • Francesco D’Angelo,
  • Tiziana La Spina,
  • Elena Dionigi,
  • Maria D’Avino,
  • Giuseppe Caruso,
  • Roberta De Angelis,
  • Sara Rotunno,
  • Stefano De Carli,
  • Sabrina Spangaro,
  • Teresiano De Franceschi,
  • Youssef Saleh,
  • Raffaella De Giovanni,
  • VogrigNadia Vogrig,
  • Giovanni Ferrari,
  • Micaela Asti,
  • Cirillo Nunzia,
  • Rebasti Daniela,
  • Anna Rita Sorrentino,
  • Maria Ferraro,
  • Javier Rosada,
  • Alessio Bonaiuto,
  • Pietro Gatti,
  • Mariangela Barletta,
  • Mauro Giordano,
  • Tiziana Ciarambino,
  • Andrea Giorgi,
  • Margherita Guarini,
  • Matteo Giorgi Pierfranceschi,
  • Matteo Migazzi,
  • Antonio Greco,
  • Carmela Gerdano,
  • Concetta Coronella,
  • Martina Lombardi,
  • Mariacarla Ventriglia,
  • Maurizio Manini,
  • Davide Lillo,
  • Larizza Giovanni,
  • Claudia Castellano,
  • Antonino Mazzone,
  • Noemi Brendaglia,
  • Alberto Moggi Pignone,
  • Antonello Ramundo,
  • Andrea Montagnani,
  • Michele Caselli,
  • Ignazio Maria Morana,
  • Angela Pastore,
  • Maria Giuseppina Pecora,
  • Michela Muriago,
  • Adriana Dal Maso,
  • Clara Pia Pafundi,
  • Paola Novati,
  • Daniela Cottarelli,
  • Gabriella Oliva,
  • Raffaella Andreozzi,
  • Filomena Pietrantonio,
  • Giampiero Marino,
  • Mario Pirisi,
  • Gian Paolo Fra,
  • Cecilia Politi,
  • Concetta Mancini,
  • Marzia Turilli,
  • Renda Maurizio,
  • Giuseppe Miceli,
  • Fabrizio Santoro,
  • Martino Rosamaria,
  • Margherita Cirillo,
  • Maurizio Tonizzo,
  • Ada Zanier,
  • Cristina Trojani,
  • Gabriella Fantini,
  • Raffaele Zoratti,
  • Cristina Pizzin,
  • Petri Roberta,
  • Girola Andrea,
  • Luconi Maria Paola,
  • Romanello Daniele,
  • Bandini Giulia,
  • Gabrielli Mariagrazia,
  • Imburgia Mariangela,
  • Copat Maria,
  • Antonini Raffaella

摘要

Few data are available regarding the adherence to treatment guidelines in individuals with type 2 diabetes mellitus (T2DM) admitted to Internal Medicine Wards (IMW) while no information is available concerning the possible efficacy of an educational intervention aimed at improving adherence in this setting. To explore guidelines adherence and the associated impact on glycemic control in subjects with T2DM hospitalized in IMW before and after an educational intervention, we conducted a 3-phase, cluster-randomized, multicenter study. During Phase 1, we retrospectively collected data from patients with T2DM hospitalized for any cause in IMW for ≥5 days. In Phase 2, an educational training, based on the method of the educational outreach visits (EOV), was developed in 36 out of the 54 centers involved. In Phase 3, conducted 6 months after the training, we replicated the collection of data performed in Phase 1. Overall, we analyzed data from 1909 and 1662 individuals with T2DM during Phase 1 and Phase 3 of the study, respectively. No changes were observed in the difference between mean fasting glycemia levels at discharge vs at admission in Phase 3 comparing EOV vs NO EOV groups. A statistically significant increase in adherence to guidelines was observed from Phase 1 to Phase 3 and a trend toward higher adherence was detected when comparing the EOV and the no EOV groups. A structured educational intervention improves adherence to guidelines for managing T2DM in individuals admitted to IMW but has no effect on short-term glycemic control.