Objective To observe the impact of Yi Jin Jing (Sinew-transforming Exercise) plus individualized exercise prescription combining treadmill training and strength training on geriatric female patients with primary osteoporosis (POP). Methods Seventy-five geriatric female POP patients were recruited and randomized into a control group, an exercise therapy group, or a combined group, with 25 cases in each group. The control group received regular treatment, including health education and oral administration of calcium carbonate and vitamin D3 granules and alendronate sodium. The exercise therapy group received treadmill-based exercise and strength training 3 times weekly in addition to the intervention given to the control group. The combined group underwent treadmill-based exercise, strength training, and Yi Jin Jing training 3 times weekly in addition to the intervention given to the control group. The intervention lasted 24 weeks in each group. Before and after treatment, the visual analog scale (VAS) score, grip strength, bone density of L1-L4 and femoral neck, and serum levels of parathyroid hormone (PTH), 25-hydroxyvitamin D3 [25(OH)D3], osteocalcin (OC), procollagen I N-terminal propeptide (PINP), and beta C-telopeptide of type I collagen (β-CTX) were compared. Results After treatment, the combined group and exercise therapy group showed a significant decrease in the VAS score and an increase in the grip strength (P<0.05). The bone density of L1-L4 and femoral head rose in all three groups after the intervention (P<0.05), together with markedly decreased serum PTH, OC, PINP, and β-CTX levels (P<0.05) and a notably increased 25(OH)D3 level (P<0.05). After treatment, the combined and exercise therapy groups had a significantly lower VAS score and higher grip strength (P<0.05) compared to the control group; the former two groups also had a higher bone density of L1-L4 and femoral head (P<0.05), lower serum PTH, PINP, and β-CTX levels (P<0.05) and a higher 25(OH)D3 level (P<0.05). Compared to the exercise therapy group, the combined group had a lower VAS score, higher L1-L4 and femoral head bone density, and lower serum PINP and β-CTX levels. Conclusion Based on regular treatment, personalized exercise prescriptions centered on Yi Jin Jing can alleviate pain, enhance grip strength and bone density, and correct abnormal expression of bone metabolism markers in geriatric females with POP.

Impact of Yi Jin Jing combined with exercise training on geriatric female patients with primary osteoporosis: a randomized controlled trial

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发表日期：

2025年8月19日

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Yongjie Li,
Mengling Liu,
Hongju Liu

摘要

Objective

To observe the impact of Yi Jin Jing (Sinew-transforming Exercise) plus individualized exercise prescription combining treadmill training and strength training on geriatric female patients with primary osteoporosis (POP).

Methods

Seventy-five geriatric female POP patients were recruited and randomized into a control group, an exercise therapy group, or a combined group, with 25 cases in each group. The control group received regular treatment, including health education and oral administration of calcium carbonate and vitamin D₃ granules and alendronate sodium. The exercise therapy group received treadmill-based exercise and strength training 3 times weekly in addition to the intervention given to the control group. The combined group underwent treadmill-based exercise, strength training, and Yi Jin Jing training 3 times weekly in addition to the intervention given to the control group. The intervention lasted 24 weeks in each group. Before and after treatment, the visual analog scale (VAS) score, grip strength, bone density of L₁-L₄ and femoral neck, and serum levels of parathyroid hormone (PTH), 25-hydroxyvitamin D₃ [25(OH)D₃], osteocalcin (OC), procollagen I N-terminal propeptide (PINP), and beta C-telopeptide of type I collagen (β-CTX) were compared.

Results

After treatment, the combined group and exercise therapy group showed a significant decrease in the VAS score and an increase in the grip strength (P<0.05). The bone density of L₁-L₄ and femoral head rose in all three groups after the intervention (P<0.05), together with markedly decreased serum PTH, OC, PINP, and β-CTX levels (P<0.05) and a notably increased 25(OH)D₃ level (P<0.05). After treatment, the combined and exercise therapy groups had a significantly lower VAS score and higher grip strength (P<0.05) compared to the control group; the former two groups also had a higher bone density of L₁-L₄ and femoral head (P<0.05), lower serum PTH, PINP, and β-CTX levels (P<0.05) and a higher 25(OH)D₃ level (P<0.05). Compared to the exercise therapy group, the combined group had a lower VAS score, higher L₁-L₄ and femoral head bone density, and lower serum PINP and β-CTX levels.

Conclusion

Based on regular treatment, personalized exercise prescriptions centered on Yi Jin Jing can alleviate pain, enhance grip strength and bone density, and correct abnormal expression of bone metabolism markers in geriatric females with POP.