<p>F<span>an</span> Zhen’s 范縝 “Shen Mie Lun 神滅論” can be read as a debate between a physicalist and a dualist in the philosophy of mind. This debate, known as the “mind-body problem” in the Western tradition, has a long history beginning with the ancient Greeks, and is still rife to this very day. Many of the arguments found in the “Shen Mie Lun” correspond to arguments found in the history of Western thought, including those of Aristotle, Descartes, Leibniz, Frege, and Ryle. My aims in this essay are threefold: (1) offer a philosophical translation and explication of the key arguments in the “Shen Mie Lun,” (2) compare them with the corresponding arguments of some relevant Western philosophers, and (3) clarify F<span>an</span> Zhen’s position on the mind-body problem through comparing the conceptual distinctions employed by him with those employed by his Western counterparts.</p>