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<p>To evaluate the surgical and oncological outcomes of robotic surgery for pT4 colorectal cancer compared with laparoscopic and open approaches. This multicenter retrospective study included 494 patients undergoing curative resection for pT4 colorectal cancer (2016–2025). Patients were categorized into robotic (R; <i>n</i> = 31), laparoscopic (L; <i>n</i> = 379), and open (O; <i>n</i> = 74) groups. Short-term outcomes and disease-free survival (DFS) were assessed. To determine independent predictors of postoperative complications, we applied multivariable logistic regression models (Trial registration: UMIN000059581). The R group achieved the lowest median blood loss (20 vs. 25 vs. 186 mL; <i>p</i> &lt; 0.001) and zero conversions, despite longer operative times (276 vs. 249 vs. 208&#xa0;min; <i>p</i> = 0.001). Complication rates (Clavien-Dindo ≥ II) were comparable among the groups (22.6%, 23.5%, and 28.4%; <i>p</i> = 0.652). In multivariable analysis, surgical approach was not associated with postoperative complications (Robotic vs. Laparoscopic: OR 0.77, 95% CI 0.28–1.87; <i>p</i> = 0.581). Regarding oncological outcomes, 3-year DFS showed similar trends across the three groups (log-rank <i>p</i> = 0.71). Robotic surgery for pT4 colorectal cancer resulted in minimal blood loss and zero conversions. The procedure demonstrated perioperative safety and feasibility comparable to laparoscopic surgery. In oncology, 3-year DFS showed similar trends, although long-term confirmation is required. Trial registration number: UMIN000059581, date of registration: October 29, 2025, retrospectively registered.</p>

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Short-term outcomes and feasibility of robotic-assisted surgery for pT4 colorectal cancer: a multicenter retrospective study

  • 期刊论文

  • 发表日期：

    2026年4月21日

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  • Kaido Oishi,
  • Tetsuro Tominaga,
  • Yuma Takamura,
  • Hiroki Katayama,
  • Shintaro Hashimoto,
  • Mariko Yamashita,
  • Mitsutoshi Ishii,
  • Hiroaki Takeshita,
  • Masaaki Moriyama,
  • Fumitake Uchida,
  • Toshio Shiraishi,
  • Keizaburo Maruyama,
  • Shozaburo Oyama,
  • Tamotsu Kuroki,
  • Takashi Nonaka,
  • Keitaro Matsumoto

摘要

To evaluate the surgical and oncological outcomes of robotic surgery for pT4 colorectal cancer compared with laparoscopic and open approaches. This multicenter retrospective study included 494 patients undergoing curative resection for pT4 colorectal cancer (2016–2025). Patients were categorized into robotic (R; n = 31), laparoscopic (L; n = 379), and open (O; n = 74) groups. Short-term outcomes and disease-free survival (DFS) were assessed. To determine independent predictors of postoperative complications, we applied multivariable logistic regression models (Trial registration: UMIN000059581). The R group achieved the lowest median blood loss (20 vs. 25 vs. 186 mL; p < 0.001) and zero conversions, despite longer operative times (276 vs. 249 vs. 208 min; p = 0.001). Complication rates (Clavien-Dindo ≥ II) were comparable among the groups (22.6%, 23.5%, and 28.4%; p = 0.652). In multivariable analysis, surgical approach was not associated with postoperative complications (Robotic vs. Laparoscopic: OR 0.77, 95% CI 0.28–1.87; p = 0.581). Regarding oncological outcomes, 3-year DFS showed similar trends across the three groups (log-rank p = 0.71). Robotic surgery for pT4 colorectal cancer resulted in minimal blood loss and zero conversions. The procedure demonstrated perioperative safety and feasibility comparable to laparoscopic surgery. In oncology, 3-year DFS showed similar trends, although long-term confirmation is required. Trial registration number: UMIN000059581, date of registration: October 29, 2025, retrospectively registered.