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<p>Fifteen phenolics, including one previously undescribed, a biflavanone diglycoside 7,7ʺ-di-<i>O</i>-β-D-glucopyranosyl-(I-3,II-3)-biliquiritigenin (<b>1</b>) along with fourteen known compounds (<b>2–15</b>) were isolated from <i>Ormocarpum sennoides</i> subsp. <i>zanzibaricum</i> aerial part by using diverse chromatographic methods. The structures of the isolates were established on the basis of detailed spectroscopic analysis (UV, ECD, IR, HRESI-MS, 1D and 2D NMR) and comparison with literature data. The antibacterial activities of these compounds were evaluated via the microdilution method against Methicillin-resistant <i>Staphylococcus aureus</i> and TolC-deficient mutant strain of <i>Salmonella enterica</i> serovar Typhimurium. Among them, sikokianin C (<b>12</b>) (MIC = 12.5 µM) and (+)-chamaejasmin (<b>13</b>) (MIC = 25 µM) demonstrated moderate antibacterial activity against Methicillin-resistant <i>Staphylococcus aureus</i>. Additionally, diphysin (<b>3</b>) and 5-<i>O</i>-methyldiphysin (<b>7</b>) both exhibited notable activity against TolC-deficient <i>S. enterica</i> serovar Typhimurium with MIC values of 50 µM. These findings support its promising potential as source of natural bioactive components possessing antibacterial properties.</p>

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Phenolic compounds with antibacterial activity from Ormocarpum sennoides subsp. zanzibaricum (Fabaceae)

  • 期刊论文

  • 发表日期：

    2026年7月28日

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  • Maryl M. T. Mamdom,
  • Eutrophe L. D. Kamto,
  • Eisuke Hosoya,
  • Ryoya Yamamoto,
  • Joséphine N. Mbing,
  • Mariko Kitajima,
  • Akiko Takaya,
  • Dieudonné E. Pegnyemb,
  • Hayato Ishikawa

摘要

Fifteen phenolics, including one previously undescribed, a biflavanone diglycoside 7,7ʺ-di-O-β-D-glucopyranosyl-(I-3,II-3)-biliquiritigenin (1) along with fourteen known compounds (2–15) were isolated from Ormocarpum sennoides subsp. zanzibaricum aerial part by using diverse chromatographic methods. The structures of the isolates were established on the basis of detailed spectroscopic analysis (UV, ECD, IR, HRESI-MS, 1D and 2D NMR) and comparison with literature data. The antibacterial activities of these compounds were evaluated via the microdilution method against Methicillin-resistant Staphylococcus aureus and TolC-deficient mutant strain of Salmonella enterica serovar Typhimurium. Among them, sikokianin C (12) (MIC = 12.5 µM) and (+)-chamaejasmin (13) (MIC = 25 µM) demonstrated moderate antibacterial activity against Methicillin-resistant Staphylococcus aureus. Additionally, diphysin (3) and 5-O-methyldiphysin (7) both exhibited notable activity against TolC-deficient S. enterica serovar Typhimurium with MIC values of 50 µM. These findings support its promising potential as source of natural bioactive components possessing antibacterial properties.