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<p>A core–shell hybrid nanocomposite consisting of a layered double hydroxide (LDH) core coated with a liposomal shell (LS) was developed to suppress the initial burst and provide gradual release of amoxicillin (AMX). The AMX–LDH nanohybrid was synthesised via a co-assembly route, followed by liposome surface modification via reverse evaporation, yielding the AMX–LDH/LS nanocomposite. Successful intercalation of AMX was confirmed by an increase in the LDH basal spacing from 9.02 to 13.97 Å, while the layered structure was maintained. Well-dispersed, spherical nanoparticles with diameters ranging from 150 to 300&#xa0;nm were formed. Taken together with the surface-charge reversal and FTIR results, this is consistent with a liposomal coating and a core–shell architecture. The surface charge shifted from + 34 mV to −15 mV, supporting lipid-mediated surface modification and suggesting steric stabilisation by the lipid shell. The drug-loading efficiency increased from 40.44% in AMX–LDH to 47.28% in the liposome-modified system. In vitro release studies showed rapid release from AMX–LDH (~ 94% at pH 4.8 and ~ 71% at pH 7.4 after 360&#xa0;min), whereas the AMX–LDH/LS exhibited sustained-release behaviour over 360&#xa0;min under the tested conditions (~ 63% at pH 4.8 and ~ 60% at pH 7.4). Kinetic analysis indicated that the release profiles were generally consistent with diffusion-controlled release, as supported by the good agreement with the Higuchi model. The release mechanism was influenced by the release media and the presence of a lipid shell, governed by a combination of ion exchange, diffusion, and membrane-controlled transport. To the best of our knowledge, this is the first study investigating lecithin/cholesterol liposome-coated MgAl–LDH as a carrier system for AMX release.</p>

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Liposome-coated layered double hydroxide nanocomposites for burst-suppressed amoxicillin release

  • 期刊论文

  • 发表日期：

    2026年7月20日

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  • Nedaa Alharbi

摘要

A core–shell hybrid nanocomposite consisting of a layered double hydroxide (LDH) core coated with a liposomal shell (LS) was developed to suppress the initial burst and provide gradual release of amoxicillin (AMX). The AMX–LDH nanohybrid was synthesised via a co-assembly route, followed by liposome surface modification via reverse evaporation, yielding the AMX–LDH/LS nanocomposite. Successful intercalation of AMX was confirmed by an increase in the LDH basal spacing from 9.02 to 13.97 Å, while the layered structure was maintained. Well-dispersed, spherical nanoparticles with diameters ranging from 150 to 300 nm were formed. Taken together with the surface-charge reversal and FTIR results, this is consistent with a liposomal coating and a core–shell architecture. The surface charge shifted from + 34 mV to −15 mV, supporting lipid-mediated surface modification and suggesting steric stabilisation by the lipid shell. The drug-loading efficiency increased from 40.44% in AMX–LDH to 47.28% in the liposome-modified system. In vitro release studies showed rapid release from AMX–LDH (~ 94% at pH 4.8 and ~ 71% at pH 7.4 after 360 min), whereas the AMX–LDH/LS exhibited sustained-release behaviour over 360 min under the tested conditions (~ 63% at pH 4.8 and ~ 60% at pH 7.4). Kinetic analysis indicated that the release profiles were generally consistent with diffusion-controlled release, as supported by the good agreement with the Higuchi model. The release mechanism was influenced by the release media and the presence of a lipid shell, governed by a combination of ion exchange, diffusion, and membrane-controlled transport. To the best of our knowledge, this is the first study investigating lecithin/cholesterol liposome-coated MgAl–LDH as a carrier system for AMX release.