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<p>Nowadays, scientists are trying to design a developed nanocarrier for delivering drugs specifically to cancerous cells. This study aimed to design the poly (acrylamide-maleic anhydride-POSS)/(FA &amp; TPGS) nanocarrier (P(AAm-MA-POSS)/(FA &amp; TPGS) NC) as a GSH-sensitive and folic acid (FA)-modified targeted drug delivery system. For this purpose, the P(AAm-MA-POSS)/(FA &amp; TPGS) copolymer was synthesized via free radical polymerization of AAm, MA, and POSS-glycidyl methacrylate (POSS-GMA) monomers, followed by chemical grafting of FA-NH<sub>2</sub> and TPGS-SS-NH<sub>2</sub>. Finally, the synthesized copolymer was self-assembled into the P(AAm-MA-POSS)/(FA &amp; TPGS) nanocarrier with a hydrophobic POSS-based core surrounded by the hydrophilic TPGS and FA moieties. Sorafenib tosylate (ST) drug was encapsulated during the nanocarrier preparation. The TEM and DLS results confirmed the successful preparation of a self-assembled nanocarrier with around 100&#xa0;nm diameter. The prepared nanocarrier exhibited enhanced cellular uptake through FA receptor-mediated endocytosis and GSH-sensitive drug release owing to the disulfide bond cleavage in the presence of reductive GSH. The efficiency of prepared ST-loaded nanocarrier against MCF-7 cancer cells was verified by MTT, and decreased amounts of the IC<sub>50</sub> for this ST-loaded nanocarrier compared to pure ST exhibited higher cytotoxicity of the drug-loaded nanocarrier. Thus, the developed targeted nanocarrier can be a suitable choice for inhibiting cancer cells.</p>

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A novel glutathione-sensitive and folic acid-modified nanocarrier for tumor-targeted drug delivery

  • 期刊论文

  • 发表日期：

    2026年6月24日

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  • Farzaneh Sadrykia,
  • Peyman Najafi Moghadam,
  • Hamed Hamishehkar

摘要

Nowadays, scientists are trying to design a developed nanocarrier for delivering drugs specifically to cancerous cells. This study aimed to design the poly (acrylamide-maleic anhydride-POSS)/(FA & TPGS) nanocarrier (P(AAm-MA-POSS)/(FA & TPGS) NC) as a GSH-sensitive and folic acid (FA)-modified targeted drug delivery system. For this purpose, the P(AAm-MA-POSS)/(FA & TPGS) copolymer was synthesized via free radical polymerization of AAm, MA, and POSS-glycidyl methacrylate (POSS-GMA) monomers, followed by chemical grafting of FA-NH2 and TPGS-SS-NH2. Finally, the synthesized copolymer was self-assembled into the P(AAm-MA-POSS)/(FA & TPGS) nanocarrier with a hydrophobic POSS-based core surrounded by the hydrophilic TPGS and FA moieties. Sorafenib tosylate (ST) drug was encapsulated during the nanocarrier preparation. The TEM and DLS results confirmed the successful preparation of a self-assembled nanocarrier with around 100 nm diameter. The prepared nanocarrier exhibited enhanced cellular uptake through FA receptor-mediated endocytosis and GSH-sensitive drug release owing to the disulfide bond cleavage in the presence of reductive GSH. The efficiency of prepared ST-loaded nanocarrier against MCF-7 cancer cells was verified by MTT, and decreased amounts of the IC50 for this ST-loaded nanocarrier compared to pure ST exhibited higher cytotoxicity of the drug-loaded nanocarrier. Thus, the developed targeted nanocarrier can be a suitable choice for inhibiting cancer cells.