Scholarlink

<p>Pencil graphite electrode (PGE) has emerged as a promising and cost-effective material for various electrochemical applications. In this study, a simple, economical, and highly efficient electrochemical sensing platform for Ornidazole (ORDZ) was developed using PGE without any additional modification or pretreatment steps. The electrochemical behavior of ORDZ was investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at different bare electrodes, including screen-printed carbon electrode (SPCE), carbon paste electrode (CPE), and glassy carbon electrode (GCE). Voltammetric results revealed that PGE exhibits a superior electrochemical response toward ORDZ reduction compared to the other electrodes. DPV measurements further demonstrated that the PGE-based sensing platform provides a low detection limit (DL: 0.075&#xa0;μM), a wide dynamic range (0.20–100&#xa0;μM), and high sensitivity (15,535&#xa0;μA&#xa0;mM<sup>−1</sup>&#xa0;cm<sup>−2</sup>) for ORDZ determination. The proposed sensor also shows excellent selectivity against common interferences (Change in response &lt; 5.0%) and high applicability for the analysis of ORDZ in pharmaceutical tablet sample (found value: 501&#xa0;mg ORDZ compared with declared dosage of 500&#xa0;mg) and artificial blood sample (recovery range: 98.6–100.8% ORDZ) with satisfactory accuracy and precision (RSD &lt; 2.0%). The developed method was successfully validated against an ultraviolet–visible (UV–Vis) spectroscopic method, showing good agreement with the reference technique.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Differential pulse voltammetric determination of Ornidazole at pencil graphite electrode: A cost-effective and reliable approach

  • 期刊论文

  • 发表日期：

    2026年4月7日

查看全文
  • Serkan Karakaya

摘要

Pencil graphite electrode (PGE) has emerged as a promising and cost-effective material for various electrochemical applications. In this study, a simple, economical, and highly efficient electrochemical sensing platform for Ornidazole (ORDZ) was developed using PGE without any additional modification or pretreatment steps. The electrochemical behavior of ORDZ was investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at different bare electrodes, including screen-printed carbon electrode (SPCE), carbon paste electrode (CPE), and glassy carbon electrode (GCE). Voltammetric results revealed that PGE exhibits a superior electrochemical response toward ORDZ reduction compared to the other electrodes. DPV measurements further demonstrated that the PGE-based sensing platform provides a low detection limit (DL: 0.075 μM), a wide dynamic range (0.20–100 μM), and high sensitivity (15,535 μA mM−1 cm−2) for ORDZ determination. The proposed sensor also shows excellent selectivity against common interferences (Change in response < 5.0%) and high applicability for the analysis of ORDZ in pharmaceutical tablet sample (found value: 501 mg ORDZ compared with declared dosage of 500 mg) and artificial blood sample (recovery range: 98.6–100.8% ORDZ) with satisfactory accuracy and precision (RSD < 2.0%). The developed method was successfully validated against an ultraviolet–visible (UV–Vis) spectroscopic method, showing good agreement with the reference technique.