<p>Greener synthetic approaches have become more significant in organic synthesis over the past decade. Green synthesis is widely accepted by organic and medicinal chemists to construct sustainable organic molecular frameworks. Due to their unusual properties, ionic liquids have received considerable attention to researchers. Quinolines are privileged scaffolds for identifying lead structures like linomide, ciprofloxacin, and hydroxychloroquine, which have considerable medicinal potential. Quinoline and its scaffolds are used in many scientific fields to create useful molecular architectures. Previous reports show that ionic liquids act as solvents, and catalysts are essential for nature-friendly quinoline derivative development. There is no systematic analysis of ionic liquids-assisted quinoline synthesis despite its advances and potential. This is the first comprehensive review that depicts the dual role of ionic liquids in creating more interesting quinoline derivatives.</p> Graphical abstract <p></p>