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<p>The reaction of copper(I) thiocyanate (CuSCN) with triphenylphosphine (PPh<sub>3</sub>) and 2,2’-dipyridylamine (dpa) in acetonitrile, at room temperature for just two hours, led to the formation of the photoluminescent complex [Cu(SCN)(PPh<sub>3</sub>)(dpa)], which exhibits intense blue-green photoluminescence in the solid state. This synthesis route represents an advancement over previously reported method that required longer reaction time and different solvent, thus offering a more efficient and practical approach. Single-crystal X-ray diffraction revealed a novel crystal structure featuring a slightly distorted tetrahedral geometry around the Cu(I) center, stabilized by P, N, and S donor atoms from the ligands and thiocyanate. The resulting Cu(I) complex was applied to fluorescent detection studies and showed a strong affinity for the pharmaceutical analytes sodium diclofenac and tetracycline hydrochloride. This interaction was evidenced by significant fluorescence quenching, low limits of detection (LOD) of 3.14&#xa0;µM for sodium diclofenac and 0.33&#xa0;µM for tetracycline hydrochloride, and high binding constants (K<sub>b</sub>) of 0.00714&#xa0;µM<sup>−1</sup> and 0.00425&#xa0;µM<sup>−1</sup>, respectively. The complex exhibited a linear fluorescence response within relevant concentration ranges, suggesting excellent sensitivity and potential applicability for detecting trace pharmaceutical residues. These findings highlight the promise of this complex as a practical and efficient sensor, with implications for environmental monitoring and pharmaceutical quality control.</p>

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Fluorescent detection of sodium diclofenac and tetracycline hydrochloride by a photoluminescent copper(I) thiocyanate-based complex

  • 期刊论文

  • 发表日期：

    2025年8月18日

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  • Simona Butan,
  • Alexandra Virginia Bounegru,
  • Sergiu Shova,
  • Aurel Tăbăcaru

摘要

The reaction of copper(I) thiocyanate (CuSCN) with triphenylphosphine (PPh3) and 2,2’-dipyridylamine (dpa) in acetonitrile, at room temperature for just two hours, led to the formation of the photoluminescent complex [Cu(SCN)(PPh3)(dpa)], which exhibits intense blue-green photoluminescence in the solid state. This synthesis route represents an advancement over previously reported method that required longer reaction time and different solvent, thus offering a more efficient and practical approach. Single-crystal X-ray diffraction revealed a novel crystal structure featuring a slightly distorted tetrahedral geometry around the Cu(I) center, stabilized by P, N, and S donor atoms from the ligands and thiocyanate. The resulting Cu(I) complex was applied to fluorescent detection studies and showed a strong affinity for the pharmaceutical analytes sodium diclofenac and tetracycline hydrochloride. This interaction was evidenced by significant fluorescence quenching, low limits of detection (LOD) of 3.14 µM for sodium diclofenac and 0.33 µM for tetracycline hydrochloride, and high binding constants (Kb) of 0.00714 µM−1 and 0.00425 µM−1, respectively. The complex exhibited a linear fluorescence response within relevant concentration ranges, suggesting excellent sensitivity and potential applicability for detecting trace pharmaceutical residues. These findings highlight the promise of this complex as a practical and efficient sensor, with implications for environmental monitoring and pharmaceutical quality control.